{"datasetrec":{"DasID":6354,"Acronym":null,"StandardTitle":"Role of cyclin-dependent kinase 5 (Cdk5) in ascidian neurogenesis","OrigTitle":null,"OrigTitleLangID":null,"OrigTitleLangCode":null,"OrigTitleLang":null,"OrigTitleLangNL":null,"VersionName":null,"ContactEmail":"sil.mercurio@gmail.com","VersionDate":null,"VersionDay":null,"VersionMonth":null,"VersionYear":null,"SizeReference":null,"EngAbstract":null,"EngDescr":"Study of the Cdk5 role in <i>C. intestinalis</i> neural development through Roscovitine treatments. While low drug concentrations did not affect larvae general morphology, the highest tested dose induced specific alterations: larvae trunk appeared roundish, characterized by a flat dorsal side and adhesive palps dorsally located; the tail was kinked and shorter than control ones. Moreover, WISH analysis employing a pan-neural gene, Ci-ETR revealed that larval central nervous system was highly affected by Roscovitine exposure. Indeed, the sensory vesicle seemed to be reduced in size and fused with the visceral ganglion, suggesting that inhibition of Cdk5 activity altered <i>Ciona</i> neural migration and synapses formation as described in vertebrates.","OrigAbstract":null,"OrigDescr":null,"Comments":null,"ReleaseDate":null,"ReleaseDate0":null,"OrigDescrLang":null,"EmbargoDate":null,"OrigDescrLangNL":null,"OrigLangCode":null,"OrigLangCodeExtended":null,"OrigLangID":null,"DescrCompFlag":0,"DescrTransFlag":0,"Citation":"Mercurio, S.; Pennati, R; Università degli Studi di Milano: Italy; (2019): Role of cyclin-dependent kinase 5 (Cdk5) in ascidian neurogenesis.","AccessConstraints":null,"UDate":"2020-04-16","CDate":"2019-11-07","CurrencyDate":null,"RevisionDate":null,"DateLastModified":{"date":"2026-05-14 01:44:00.153333","timezone_type":1,"timezone":"+02:00"},"CheckedFlag":0,"PublicFlag":1,"VlizCoreFlag":1,"MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"StatusID":1,"DasType":"Data","DasTypeID":1,"DasOrigin":"Research: lab experiment","Progress":"In Progress","AccessConstraint":"Unrestricted after moratorium period","AccConstrEN":"Unrestricted after moratorium period","AccConstrDisplay":null,"License":null,"AccConstrDescription":"Data are initially restricted, but the access condition relaxes to academic or unrestricted once a specified period of time after an event (such as collection, publication, completion of QC procedures or project cessation) has elapsed","Lineage":null,"AccConID":8},"dois":null,"spcols":null,"keywords":[{"ThesaurusTerm":"ANE, France, Brittany, Roscoff","ThesTypID":34,"ThesType":"ASFA Geoterms","Code":null,"Description":null,"OrigThesTerm":"ANE, France, Brittany, Roscoff","DutchTerm":null,"URI":null,"DasKeywordDescr":null},{"ThesaurusTerm":"cyclin-dependent kinase 5 (Cdk5)","ThesTypID":0,"ThesType":null,"Code":null,"Description":null,"OrigThesTerm":"cyclin-dependent kinase 5 (Cdk5)","DutchTerm":null,"URI":null,"DasKeywordDescr":null},{"ThesaurusTerm":"neurogenesis","ThesTypID":0,"ThesType":null,"Code":null,"Description":null,"OrigThesTerm":"neurogenesis","DutchTerm":null,"URI":null,"DasKeywordDescr":null},{"ThesaurusTerm":"Roscovitine treatment","ThesTypID":0,"ThesType":null,"Code":null,"Description":null,"OrigThesTerm":"Roscovitine treatment","DutchTerm":null,"URI":null,"DasKeywordDescr":null},{"ThesaurusTerm":"Whole-Mount In Situ Hybridization (WISH)","ThesTypID":0,"ThesType":null,"Code":null,"Description":null,"OrigThesTerm":"Whole-Mount In Situ Hybridization (WISH)","DutchTerm":null,"URI":null,"DasKeywordDescr":null}],"parents":null,"children":null,"othrel":null,"othrelrev":null,"ownerships":null,"taxterms":[{"DasTaxtTypID":1,"DasTaxtType":"Taxonomic coverage","TaxtID":19381,"TaxTerm":"Ascidiacea","AphiaID":1839,"DutchTerm":"Zakpijpen"},{"DasTaxtTypID":1,"DasTaxtType":"Taxonomic coverage","TaxtID":17308,"TaxTerm":"Ciona intestinalis (Linnaeus)","AphiaID":103732,"DutchTerm":"Doorschijnende zakpijp"}],"frameworks":null,"otherterms":[{"OtherTerm":"cyclin-dependent kinase 5 (Cdk5)"},{"OtherTerm":"neurogenesis"},{"OtherTerm":"Roscovitine treatment"},{"OtherTerm":"Whole-Mount In Situ Hybridization (WISH)"}],"temporal":null,"geographical":[{"GeoTerm":"Roscoff","DasGeoID":10538,"DasGeoTerm":null,"DasID":6354,"GeotID":297,"X":null,"Y":null,"MaxX":null,"MaxY":null,"StationName":null,"Precision":null,"CoordSystID":null,"GeoDatumID":null,"OrigCoordMinX":null,"OrigCoordMinY":null,"OrigCoordMaxX":null,"OrigCoordMaxY":null,"OrderNr":null,"Projection":null,"GeoDatum":null,"GeoObjectID":14276,"OrigGeoTerm":"Roscoff","DutchTerm":null}],"meastypes":null,"dasthemes":[{"DasThemeID":29,"DasTheme":"Biology > Invertebrates","DasTheme0":"Invertebrates","DutchTerm":"Invertebraten"}],"projects":[{"ProID":4868,"Acronym":"ASSEMBLE+","Progress":"Completed","StandardTitle":"Association of European Marine Biological Laboratories Expanded","FP7Code":null,"GrantDOI":null,"FunderID":"730984","FunderIDType":"EU contract id","FunderCodes":["Horizon Europe"]}],"refs":null,"urls":null,"pictures":null,"urlmaps":null,"spatreps":null,"fileformats":null,"resmessage":"","complete":1}