{"instituterec":{"StatusID":1,"InsID":14389,"StandardName":"Moleculaire Bio-ontdekking","OrigName":"Laboratory for Molecular Biodiscovery","OrigNameLangCode":"en","OrigNameLangID":15,"Acronym":"KULeuven","HigherInsID":4674,"VlizCoreFlag":1,"AdrID":162680,"Line1":null,"Line2":null,"Line3":null,"Line4":null,"Phone":null,"GSM":null,"Email":null,"Lat":null,"Lon":null,"OrigNameLang":"English","OrigNameLangNL":"Engels","AbstractEnglish":"The laboratory for Molecular Biodiscovery is a zebrafish-based platform for small-molecule drug discovery for CNS disorders and the evaluation of drug-induced organ toxicities. The group has experience in high-throughput behavioral and seizure assays, whole mount in situ hybridisation, EEG whole brain recording, transgenic zebrafish lines, antisense knockdowns, fluorescence microscopy and cryotome sectioning. \r\n\r\nThe marine component includes the zebrafish-based discovery of antiseizure compounds from the North Sea and Red Sea.","AbstractOtherLang":"Het laboratorium voor Moleculaire Bio-ontwikkeling is een zebravis-gebaseerd platform voor de ontdekking van kleine molecule-geneesmiddelen voor CNS-stoornissen en de evaluatie van geneesmiddel-geïnduceerde orgaantoxiciteit. De groep heeft ervaring met high-throughput gedrags- en epileptische tests, whole mount in situ hybridisatie, EEG hersenregistratie, transgene zebravislijnen, antisense knockdowns, fluorescentiemicroscopie en cryotome secties. \r\n\r\nDe mariene component omvat de ontdekking van anti-epileptica uit de Noordzee en de Rode Zee door zebravissen. ","AbstractLangCode":null,"AbstractLangID":null,"AbstractLang":null,"AbstractLangNL":null,"SuccessorOfInsID":null,"DateLastModified":{"date":"2024-06-04 01:34:19.073000","timezone_type":1,"timezone":"+00:00"},"PrevIns":null,"PrevAcro":null,"PublicFlag":1,"CheckedFlag":0,"ParID":2957,"InstituteType":"Scientific","EnvName":null,"ISO3166":null,"LevelName":null,"ND":"2019-10-02","UD":"2022-09-28","EncAddress":""},"parent":{"PublicFlag":1,"InsID":4674,"OrigNameLangCode":null,"OrigNameLangID":null,"FullStandardName":"KU Leuven; Departement Farmaceutische en Farmacologische Wetenschappen","FullOrigName":null,"Acronym":"KULeuven"},"institutes":null,"references":[{"BRefID":382898,"RR":"<b>Kokkini, M.; Oves-Costales, D.; Sanchez, P.; Melguizo, A.; Mackenzie, T.A.; Perez-Bonilla, M.; Martin, J.; Giusti, A.; de Witte, P.; Vicente, F.; Genilloud, O.; Reyes, F.</b> (2023). New phocoenamicin and maklamicin analogues from cultures of three marine-derived <i>Micromonospora</i> strains. <i>Mar. Drugs 21(8)</i>: 443. <a href=\"https://dx.doi.org/10.3390/md21080443\" target=\"_blank\">https://dx.doi.org/10.3390/md21080443</a>","PeerRev":1},{"BRefID":352761,"RR":"<b>Copmans, D.; Kildgaard, S.; Roux, E.; Partoens, M.; Steurs, G.; Wang, X.; De Borggraeve, W.M.; Esguerra, C.V.; Crawford, A.D.; Larsen, T.O.; de Witte, P.A.M.</b> (2022). From the North Sea to drug repurposing, the antiseizure activity of halimide and plinabulin. <i>Pharmaceuticals 15(2)</i>: 247. <a href=\"https://dx.doi.org/10.3390/ph15020247\" target=\"_blank\">https://dx.doi.org/10.3390/ph15020247</a>","PeerRev":1},{"BRefID":322870,"RR":"<b>Copmans, D.; Kildgaard, S.; Rasmussen, S.A.; Ślęzak, M.; Dirkx, N.; Partoens, M.; Esguerra, C.V.; Crawford, A.D.; Larsen, T.O.; de Witte, P.A.M.</b> (2019). Zebrafish-based discovery of antiseizure compounds from the North Sea: isoquinoline alkaloids TMC-120A and TMC-120B. <i>Mar. Drugs 17(11)</i>: 607. <a href=\"https://dx.doi.org/10.3390/md17110607\" target=\"_blank\">https://dx.doi.org/10.3390/md17110607</a>","PeerRev":1},{"BRefID":307953,"RR":"<b>Copmans, D.; Rateb, M.; Tabudravu, J.N.; Perez-Bonilla, M.; Dirkx, N.; Vallorani, R.; Diaz, C.; del Palacio, J.P.; Smith, A.J.; Ebel, R.; Reyes, F.; Jaspars, M.; de Witte, P.A.M.</b> (2018). Zebrafish-based discovery of antiseizure compounds from the Red Sea: pseurotin A<sub>2</sub> and Azaspirofuran A. <i>ACS Chemical Neuroscience 9(7)</i>: 1652-1662. <a href=\"https://dx.doi.org/10.1021/acschemneuro.8b00060\" target=\"_blank\">https://dx.doi.org/10.1021/acschemneuro.8b00060</a>","PeerRev":1},{"BRefID":293727,"RR":"<b>Sonnenschein, E.C.; Stierhof, M.; Goralczyk, S.; Vabre, F.M.; Pellissier, L.; Hanssen, K.O.; de la Cruz, M.; Diaz, C.; de Witte, P.; Copmans, D.; Andersen, J.H.; Hansen, E.; Tormo, J.R.; Ebel, R.; Milne, B.F.; Deng, H.; Gram, L.; Jaspars, M.; Tabudravu, J.N.</b> (2017). Pseudochelin A, a siderophore of <i>Pseudoalteromonas piscicida</i> S2040. <i>Tetrahedron 73(18)</i>: 2633-2637. <a href=\"https://dx.doi.org/10.1016/j.tet.2017.03.051\" target=\"_blank\">https://dx.doi.org/10.1016/j.tet.2017.03.051</a>","PeerRev":1},{"BRefID":252680,"RR":"<b>Jaspars, M.; De Pascale, D.; Andersen, J.H.; Reyes, F.; Crawford, A.D.; Ianora, A.</b> (2016). The marine biodiscovery pipeline and ocean medicines of tomorrow. <i>J. Mar. Biol. Ass. U.K. 96(1)</i>: 151-158. <a href=\"https://hdl.handle.net/10.1017/s0025315415002106\" target=\"_blank\">https://hdl.handle.net/10.1017/s0025315415002106</a>","PeerRev":1}],"conferences":null,"datasets":null,"persons":[{"PersID":44473,"Surname":"Annelii","Firstname":"Ny","Initials":null,"DirectorFlag":null,"MarineSciFlag":1,"SpecializedFlag":null,"Function":null},{"PersID":38767,"Surname":"Copmans","Firstname":"Daniëlle","Initials":"D.","DirectorFlag":null,"MarineSciFlag":null,"SpecializedFlag":null,"Function":null},{"PersID":38773,"Surname":"de Witte","Firstname":"Peter","Initials":"P.A.M.","DirectorFlag":null,"MarineSciFlag":null,"SpecializedFlag":null,"Function":null}],"pastpers":[{"PersID":38771,"Surname":"Crawford","Firstname":"Alexander","Initials":"A.D.","DirectorFlag":null,"MarineSciFlag":null,"SpecializedFlag":null,"Function":null},{"PersID":38769,"Surname":"Dirkx","Firstname":"Nina","Initials":"N.","DirectorFlag":null,"MarineSciFlag":null,"SpecializedFlag":null,"Function":null},{"PersID":38770,"Surname":"Partoens","Firstname":"Michèle","Initials":"M.","DirectorFlag":null,"MarineSciFlag":null,"SpecializedFlag":null,"Function":null},{"PersID":41202,"Surname":"Roux","Firstname":"Emma","Initials":"E.","DirectorFlag":null,"MarineSciFlag":null,"SpecializedFlag":null,"Function":null},{"PersID":38766,"Surname":"Slezak","Firstname":"Monika","Initials":"M.","DirectorFlag":null,"MarineSciFlag":null,"SpecializedFlag":null,"Function":null},{"PersID":38975,"Surname":"Vallorani","Firstname":"Riccardo","Initials":"R.","DirectorFlag":null,"MarineSciFlag":null,"SpecializedFlag":null,"Function":null}],"subpers":null,"projects":null,"urls":[{"URL":"https://gbiomed.kuleuven.be/english/research/50000715/52455311","externalID":null,"URLTypeCode":null,"URLType":"Institute home page"}],"pictures":[],"published":null,"affrefs":null,"collections":null,"thesterms":[{"ThesaurusTerm":"Biochemistry","ThestID":181483,"ThesTypID":29,"ThesType":"MOG Topics"},{"ThesaurusTerm":"Molecular biology","ThestID":181511,"ThesTypID":29,"ThesType":"MOG Topics"}],"taxterms":null,"geoterms":null,"thestermsFRIS":[{"ThesaurusTerm":"Biochemistry","DutchTerm":"Biochemie","ThestID":181483,"ThesTypID":29,"ThesType":"MOG Topics","Code":null},{"ThesaurusTerm":"Molecular biology","DutchTerm":"Moleculaire biologie","ThestID":181511,"ThesTypID":29,"ThesType":"MOG Topics","Code":null}],"nXtins":null,"previns":null,"spcols":[{"SpColID":99,"SpName":"Marine expertise"},{"SpColID":121,"SpName":"Marine expertise: Type: Flemish university"}],"resmessage":"","complete":1,"participantrec":null,"peerrevs":6,"urlmaps":[]}