{"instituterec":{"StatusID":1,"InsID":14394,"StandardName":"Research group of Developmental Neurobiology","OrigName":"Research group of Developmental Neurobiology","OrigNameLangCode":"en","OrigNameLangID":15,"Acronym":"KULeuven","HigherInsID":8899,"VlizCoreFlag":1,"AdrID":162688,"Line1":"Naamsestraat 61","Line2":"box 2464","Line3":"3000 Leuven","Line4":null,"Phone":null,"GSM":null,"Email":null,"Lat":null,"Lon":null,"OrigNameLang":"English","OrigNameLangNL":"Engels","AbstractEnglish":"Our human brain contains billions of neurons and glial cells grouped together into functional circuits. These cellular components of the brain are formed during development at distinct places, and at different time points. Neurogenesis, neural migration and initial wiring are controlled by molecular pathways in which neuron-environment or neuron-target recognition play a central role. In terms of factors mediating these recognition processes it is clear that a large number of structurally diverse surface receptors play a key role. Part of the research studied at research group of Developmental Neurobiology (Seuntjens lab) revolves around the study of Protocadherins (PCDH), which are large transmembrane proteins with tentative functions in cell-cell recognition, neural development and cancer metastasis in vertebrates.\r\n\r\nPCDH have also been found to be expanded in coleoid cephalopods such as octopus, squid and cuttlefish. These are mollusks, but have large nervous systems containing half a billion neurons, which is in the same range as mammals. The lab studies how the nervous system of these animals develops, what cell type diversity is generated, how this brain generates particular behaviors, and to what extent genomic innovations like PCDH gene expansions are involved.","AbstractOtherLang":"Ons menselijk brein bevat miljarden neuronen en gliacellen die gegroepeerd zijn in functionele circuits. Deze cellulaire componenten van de hersenen worden tijdens de ontwikkeling op verschillende plaatsen en op verschillende tijdstippen gevormd. Neurogenese, neurale migratie en initiële bedrading worden gecontroleerd door moleculaire routes waarin neuron-omgeving of neuron-doelherkenning een centrale rol spelen. Wat betreft de factoren die deze herkenningsprocessen mediëren, is het duidelijk dat een groot aantal structureel diverse receptoren aan het oppervlak een sleutelrol spelen. Een deel van het onderzoek in de onderzoeksgroep voor Developmental Neurobiology (Seuntjens lab) draait rond de studie van Protocadherines (PCDH), grote transmembraaneiwitten met vermoedelijke functies in cel-celherkenning, neurale ontwikkeling en kanker metastase in vertebraten.\r\n\r\nPCDH blijken ook uitgebreid te zijn in coleoïde koppotigen zoals octopus, inktvis en zeekat. Dit zijn weekdieren, maar ze hebben grote zenuwstelsels die een half miljard neuronen bevatten, wat in hetzelfde bereik ligt als bij zoogdieren. Het laboratorium bestudeert hoe het zenuwstelsel van deze dieren zich ontwikkelt, welke celtypendiversiteit wordt gegenereerd, hoe dit brein bepaald gedrag genereert en in hoeverre genomische innovaties zoals PCDH-genuitbreidingen hierbij betrokken zijn.","AbstractLangCode":null,"AbstractLangID":null,"AbstractLang":null,"AbstractLangNL":null,"SuccessorOfInsID":null,"DateLastModified":{"date":"2024-06-04 01:34:19.073000","timezone_type":1,"timezone":"+00:00"},"PrevIns":null,"PrevAcro":null,"PublicFlag":1,"CheckedFlag":0,"ParID":2957,"InstituteType":null,"EnvName":null,"ISO3166":null,"LevelName":null,"ND":"2019-10-11","UD":"2021-10-29","EncAddress":", Naamsestraat 61, box 2464, 3000 Leuven"},"parent":{"PublicFlag":1,"InsID":8899,"OrigNameLangCode":null,"OrigNameLangID":null,"FullStandardName":"Katholieke Universiteit Leuven; Departement Biologie; Afdeling Dierenfysiologie en Neurobiologie","FullOrigName":"University of Leuven; Department of Animal Physiology and Neurobiology","Acronym":"KULeuven"},"institutes":null,"references":[{"BRefID":391499,"RR":"<b>Baden, T.; Briseno, J.; Coffing, G.; Cohen-Bodenes, S.; Courtney, A.; Dickerson, D.; Dolen, G.; Fiorito, G.; Gestal, C.; Gustafson, T.; Heath-Heckman, E.; Hua, Q.; Imperadore, P.; Kimbara, R.; Krol, M.; Lajbner, Z.; Lichilin, N.; Macchi, F.; McCoy, M.J.; Nishiguchi, M.K.; Nyholm Spencer, S.; Otjacques, E.; Perez-Ferrer, P.A.; Ponte, G.; Pungor, J.R.; Rogers, T.F.; Rosenthal, J.J.C.; Rouressol, L.; Rubas, N.; Sanchez, G.; Santos, C.P.; Schultz, D.T.; Seuntjens, E.; Songco-Casey, J.O.; Stewart, I.E.; Styfhals, R.; Tuanapaya, S.; Vijayan, N.; Weissenbacher, A.; Zifcakova, L.; Schulz, G.; Weertman, W.; Simakov, O.; Albertin, C.B.</b> (2023). Cephalopod-omics: emerging fields and technologies in cephalopod biology. <i>Integrative and Comparative Biology 63(6)</i>: 1226-1239. <a href=\"https://dx.doi.org/10.1093/icb/icad087\" target=\"_blank\">https://dx.doi.org/10.1093/icb/icad087</a>","PeerRev":1},{"BRefID":391466,"RR":"<b>Destanovic, D.; Schultz, D.T.; Styfhals, R.; Cruz, F.; Gomez-Garrido, J.; Gut, M.; Gut, I.; Fiorito, G.; Simakov, O.; Alioto, T.S.; Ponte, G.; Seuntjens, E.</b> (2023). A chromosome-level reference genome for the common octopus, <i>Octopus vulgaris</i> (Cuvier, 1797). <i>G3-Genes Genomes Genetics 13(12)</i>: jkad220. <a href=\"https://dx.doi.org/10.1093/g3journal/jkad220\" target=\"_blank\">https://dx.doi.org/10.1093/g3journal/jkad220</a>","PeerRev":1},{"BRefID":391547,"RR":"<b>Styfhals, R.; Zolotarov, G.; Hulselmans, G.; Spanier, K.I.; Poovathingal, S.; Elagoz, A.M.; De Winter, S.; Deryckere, A.; Rajewsky, N.; Ponte, G.; Fiorito, G.; Aerts, S.; Seuntjens, E.</b> (2022). Cell type diversity in a developing octopus brain. <i>Nature Comm. 13(1)</i>: 7392. <a href=\"https://dx.doi.org/10.1038/s41467-022-35198-1\" target=\"_blank\">https://dx.doi.org/10.1038/s41467-022-35198-1</a>","PeerRev":1},{"BRefID":391548,"RR":"<b>Zolotarov, G.; Fromm, B.; Legnini, I.; Ayoub, S.; Polese, G.; Maselli, V.; Chabot, P.J.; Vinther, J.; Styfhals, R.; Seuntjens, E.; Di Cosmo, A.; Peterson, K.J.; Rajewsky, N.</b> (2022). MicroRNAs are deeply linked to the emergence of the complex octopus brain. <i>Science Advances 8(47)</i>: eadd9938. <a href=\"https://dx.doi.org/10.1126/sciadv.add9938\" target=\"_blank\">https://dx.doi.org/10.1126/sciadv.add9938</a>","PeerRev":1},{"BRefID":353282,"RR":"<b>Deryckere, A.; Styfhals, R.; Elagoz, A.M.; Maes, G.E.; Seuntjens, E.</b> (2021). Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain. <i>eLIFE 10</i>: e69161. <a href=\"https://dx.doi.org/10.7554/eLife.69161\" target=\"_blank\">https://dx.doi.org/10.7554/eLife.69161</a>","PeerRev":1},{"BRefID":337892,"RR":"<b>Deryckere, A.; Styfhals, R.; Vidal, E.A.G.; Almansa, E.; Seuntjens, E.</b> (2020). A practical staging atlas to study embryonic development of <i>Octopus vulgaris</i> under controlled laboratory conditions. <i>Bmc Developmental Biology 20(1)</i>: 7. <a href=\"https://hdl.handle.net/10.1186/s12861-020-00212-6\" target=\"_blank\">https://hdl.handle.net/10.1186/s12861-020-00212-6</a>","PeerRev":1},{"BRefID":312191,"RR":"<b>Montanino, A.; Deryckere, A.; Famaey, N.; Seuntjens, E.; Kleiven, S.</b> (2019). Mechanical characterization of squid giant axon membrane sheath and influence of the collagenous endoneurium on its properties. <i>NPG Scientific Reports 9(1)</i>: 10 pp. <a href=\"https://dx.doi.org/10.1038/s41598-019-45446-y\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-019-45446-y</a>","PeerRev":1},{"BRefID":310402,"RR":"<b>Styfhals, R.; Seuntjens, E.; Simakov, O.; Sanges, R.; Fiorito, G.</b> (2019). <i>In silico</i> identification and expression of protocadherin gene family in <i>Octopus vulgaris</i>. <i>Frontiers in Physiology 9</i>: 1905. <a href=\"https://dx.doi.org/10.3389/fphys.2018.01905\" target=\"_blank\">https://dx.doi.org/10.3389/fphys.2018.01905</a>","PeerRev":1},{"BRefID":323228,"RR":"<b>Zarrella, I.; Herten, K.; Maes, G.E.; Tai, S.; Yang, M.; Seuntjens, E.; Ritschard, E.A.; Zach, M.; Styfhals, R.; Sanges, R.; Simakov, O.; Ponte, G.; Fiorito, G.</b> (2019). The survey and reference assisted assembly of the <i>Octopus vulgaris</i> genome. <i>Scientific Data 6</i>: 13. <a href=\"https://dx.doi.org/10.1038/s41597-019-0017-6\" target=\"_blank\">https://dx.doi.org/10.1038/s41597-019-0017-6</a>","PeerRev":1},{"BRefID":307929,"RR":"<b>Deryckere, A.; Seuntjens, E.</b> (2018). The cephalopod large brain enigma: are conserved mechanisms of stem cell expansion the key? <i>Frontiers in Physiology 9</i>: 8. <a href=\"https://dx.doi.org/10.3389/fphys.2018.01160\" target=\"_blank\">https://dx.doi.org/10.3389/fphys.2018.01160</a>","PeerRev":1}],"conferences":null,"datasets":null,"persons":[{"PersID":44644,"Surname":"Maccuro","Firstname":"Sofia","Initials":null,"DirectorFlag":null,"MarineSciFlag":1,"SpecializedFlag":null,"Function":null},{"PersID":44663,"Surname":"Murat Elagoz","Firstname":"Ali","Initials":null,"DirectorFlag":null,"MarineSciFlag":1,"SpecializedFlag":null,"Function":null},{"PersID":37228,"Surname":"Seuntjens","Firstname":"Eve","Initials":"E.","DirectorFlag":null,"MarineSciFlag":null,"SpecializedFlag":null,"Function":null},{"PersID":37634,"Surname":"Styfhals","Firstname":"Ruth","Initials":"R.","DirectorFlag":null,"MarineSciFlag":null,"SpecializedFlag":null,"Function":null}],"pastpers":[{"PersID":37227,"Surname":"Deryckere","Firstname":"Astrid","Initials":"A.","DirectorFlag":null,"MarineSciFlag":null,"SpecializedFlag":null,"Function":null}],"subpers":null,"projects":null,"urls":[{"URL":"https://bio.kuleuven.be/df/es","externalID":null,"URLTypeCode":null,"URLType":"Institute home page"}],"pictures":[],"published":null,"affrefs":null,"collections":null,"thesterms":[{"ThesaurusTerm":"Biochemistry","ThestID":181483,"ThesTypID":29,"ThesType":"MOG Topics"},{"ThesaurusTerm":"Molecular biology","ThestID":181511,"ThesTypID":29,"ThesType":"MOG Topics"}],"taxterms":null,"geoterms":null,"thestermsFRIS":[{"ThesaurusTerm":"Biochemistry","DutchTerm":"Biochemie","ThestID":181483,"ThesTypID":29,"ThesType":"MOG Topics","Code":null},{"ThesaurusTerm":"Molecular biology","DutchTerm":"Moleculaire biologie","ThestID":181511,"ThesTypID":29,"ThesType":"MOG Topics","Code":null}],"nXtins":null,"previns":null,"spcols":[{"SpColID":99,"SpName":"Marine expertise"},{"SpColID":121,"SpName":"Marine expertise: Type: Flemish university"}],"resmessage":"","complete":1,"participantrec":null,"peerrevs":10,"urlmaps":[]}