{"refrec":{"BRefID":101697,"RR":"<b>Martin-Skilton, R.; Coughtrie, M.W.H.; Porte, C.</b> (2006). Sulfotransferase activities towards xenobiotics and estradiol in two marine fish species (<i>Mullus barbatus</i> and <i>Lepidorhombus boscii</i>): characterization and inhibition by endocrine disrupters. <i>Aquat. Toxicol. 79(1)</i>: 24-30. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2006.04.012\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2006.04.012</a>","BEntID":96785,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Aquat. Toxicol. 79(1)</i>: 24-30. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2006.04.012\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2006.04.012</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Martin-Skilton, R.; Coughtrie, M.W.H.; Porte, C.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Martin-Skilton, R.; Coughtrie, M.W.H.; Porte, C.","Englishabstract":"We have characterized hepatic phenol sulfotransferase (SULT) activities in two benthic fish species, <i>Mullus barbatus</i> and <i>Lepidorhombus boscii</i>, using <i>p</i>-nitrophenol, dopamine, 17β-estradiol, 4-nonylphenol, and 1-naphthol as substrates. High affinity sulfation of 17β-estradiol was observed in both species (<i>K</i><sub>m</sub> <tt>=</tt> 28–75 nM), suggesting the presence of a specific estrogen sulfotransferase that catalyzes the formation of estradiol-3 sulfate. Among the tested compounds, 1-naphthol was the most effective substrate for sulfation, with <i>V</i><sub>max</sub>/<i>K</i><sub>m</sub> ratios several hundred-fold higher than the other substrates examined. Both species sulfated the tested compounds, but only <i>M. barbatus</i> was able to sulfate dopamine. We also tested the inhibitory effects of common marine pollutants with estrogenic (4-nonylphenol) and androgenic (tributyltin, triphenyltin) properties on <i>p</i>-nitrophenol and 17β-estradiol SULT activities. 4-Nonylphenol and triphenyltin inhibited sulfation of both substrates at micromolar concentrations in both species. However, tributyltin was only effective against SULTs from <i>L. boscii</i>, again at micromolar concentrations. The data indicate that <i>M. barbatus</i> and <i>L. boscii</i> are able to sulfate a range of xenobiotics and endogenous compounds, and inhibition of these activities by environmental pollutants may contribute to the known toxic effects of these compounds.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Sulfotransferase activities towards xenobiotics and estradiol in two marine fish species (<i>Mullus barbatus</i> and <i>Lepidorhombus boscii</i>): characterization and inhibition by endocrine disrupters","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-06 01:32:19.979713","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"sulfotransferases; estradiol; endocrine disruption; fish; nonylphenol;organotin compounds","OtherDescriptors":null,"Notes":null,"AnaPub":2006,"MonPub":null,"DateUpdate":"2020-10-20","DateCreate":"2006-08-24","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000239675900004","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.aquatox.2006.04.012"},"refs":null,"anarec":{"AnaID":101697,"PubliDate":2006,"Pagination":"24-30","XtraPublOfAnaID":null,"ISBN":null,"Volume":"79","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42203,"SerRR":"Aquatic Toxicology. 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