{"refrec":{"BRefID":101700,"RR":"<b>Rocher, B.; Le Goff, J.; Peluhet, L.; Briand, M.; Manduzio, H.; Gallois, J.; Devier, M.H.; Geffard, O.; Gricourt, L.; Augagneur, S.; Budzinski, H.; Pottier, D.; André, V.; Lebailly, P.; Cachot, J.</b> (2006). Genotoxicant accumulation and cellular defence activation in bivalves chronically exposed to waterborne contaminants from the Seine River. <i>Aquat. Toxicol. 79(1)</i>: 65-77. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2006.05.005\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2006.05.005</a>","BEntID":96788,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Aquat. Toxicol. 79(1)</i>: 65-77. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2006.05.005\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2006.05.005</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Rocher, B.; Le Goff, J.; Peluhet, L.; Briand, M.; Manduzio, H.; Gallois, J.; Devier, M.H.; Geffard, O.; Gricourt, L.; Augagneur, S.; Budzinski, H.; Pottier, D.; André, V.; Lebailly, P.; Cachot, J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Rocher, B. <i>et al.</i>","Englishabstract":"The aim of the present work was to investigate genotoxicant accumulation and biological responses of zebra mussels and blue mussels collected along a pollution gradient in the Seine estuary and in the Seine Bay. The sampling area included three contaminated and one reference sites for each species. The study focused on polyaromatic hydrocarbons (PAH), lindane, polychlorobiphenyls (PCB) and metals known to be potential genotoxicants and/or reactive oxygen species (ROS) inducers. Enzymatic activities related to cellular defence systems including the phase II enzyme glutathione S-transferase (GST) and three antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathion peroxydase (GPx) were measured in gills. DNA adducts and DNA strand breaks (Comet assay) were measured in digestive gland and hemocytes, respectively. Species differences were observed in metal accumulation (As and Pb), GPx activity and DNA adduct formation. A marked upstream–downstream gradient was reported for PAH body burden and to a lesser extent for PCB and metals with the highest values measured just downstream the industrialized area of Rouen. GST and SOD activities in gills of bivalves were positively related to PAH and metals body burden, respectively. Activation of those cellular defences may prevent accumulation of electrophilic metabolites and free radicals and thus may protect DNA and others macromolecules against oxidation and adduction. Although DNA strand breaks and bulky adducts were detected in both species, levels were relatively low and no significant site differences were observed in June 2003. Our results indicate a clear relationship between genotoxicant accumulation and positive activation of detoxification and antioxidant systems but poor consequences in term of DNA damage for wild population of mussels inhabiting the Seine estuary.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Genotoxicant accumulation and cellular defence activation in bivalves chronically exposed to waterborne contaminants from the Seine River","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-11 01:31:33.675173","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"blue mussel; zebra mussel; metals; PAH; PCB; bulky DNA adducts; cometassay; Cu/Zn superoxide dismutase; glutathione peroxydase; catalase;glutathione S-transferase","OtherDescriptors":null,"Notes":null,"AnaPub":2006,"MonPub":null,"DateUpdate":"2020-10-20","DateCreate":"2006-08-25","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000239675900009","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.aquatox.2006.05.005"},"refs":null,"anarec":{"AnaID":101700,"PubliDate":2006,"Pagination":"65-77","XtraPublOfAnaID":null,"ISBN":null,"Volume":"79","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42203,"SerRR":"Aquatic Toxicology. 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