Document of bibliographic reference 102590

BibliographicReference record

Type
Bibliographic resource
Type of document
Journal article
BibLvlCode
AM
Title
Distribution and ecotoxicity of chlorotriazines in the Scheldt estuary (Belgium-Netherlands)
Abstract
The continuous introduction of new products used as growth promoters in animal husbandry, for sports doping and as products for body-building requires residue laboratories to initiate research on developing a strategy for the identification of ’unknown’ components. In this study, a strategy is presented for elucidating the identity, the structure and the possible effects of illegal estrogenic compounds in an unidentified water-based solution. To obtain complete information on the composition and activity of the unidentified product, a multidisciplinary approach was needed. A case-study is described with a ’solution X’ found during a raid. First, in vivo techniques (animal trials with mice, anatomical and histological research) were combined with in vitro techniques (the yeast estrogenic screen (YES)). In a later stage of the investigation, HPLC-fractionation, liquid chromatography–multiple mass spectrometry (LC-MS n and gas chromatography-multiple mass spectrometry (GC-MS n were used. Finally, the identity of ’solution X’ was confirmed in a very low concentration range (10 ng/L estrone and 400 ng/l ethinyloestradiol).
Bibliographic citation
Noppe, H.; Ghekiere, A.; Verslycke, T.; De Wulf, E.; Verheyden, K.; Monteyne, E.; Polfliet, K.; Van Caeter, P.; Janssen, C.R.; De Brabander, H.F. (2006). Distribution and ecotoxicity of chlorotriazines in the Scheldt estuary (Belgium-Netherlands), in: Noppe, H. Analytiek van hormoon verstorende stoffen in milieumatrices = Analytics of endocrine disrupting chemicals in environmental matrices. pp. 85-105
Topic
Marine

Authors

author
Name
Herlinde Noppe
author
Name
An Ghekiere
author
Name
Tim Verslycke
author
author
Name
Karolien Verheyden
author
Name
Els Monteyne
author
author
Name
Peter Van Caeter
author
Name
Colin Janssen
Identifier
https://orcid.org/0000-0002-7781-6679
author

thesaurus terms

term
Belgium, Schelde R. (term code: 183117 - defined in term set: ASFA Geoterms)
Ecotoxicology (term code: 9505 - defined in term set: ASFA Thesaurus List)

geographic terms

geographic terms associated with this publication
Schelde

Document metadata

date created
2006-10-02
date modified
2007-07-20