{"refrec":{"BRefID":10905,"RR":"<b>Calleja, M.C.; Persoone, G.; Geladi, P.</b> (1994). Comparative acute toxicity of the first 50 Multicenter Evaluation of <i>In Vitro</i> Cytotoxicity chemicals to aquatic non-vertebrates. <i>Arch. Environ. Contam. Toxicol. 26</i>: 69-78. <a href=\"https://dx.doi.org/10.1007/BF00212796\" target=\"_blank\">https://dx.doi.org/10.1007/BF00212796</a>","BEntID":10905,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Arch. Environ. Contam. Toxicol. 26</i>: 69-78. <a href=\"https://dx.doi.org/10.1007/BF00212796\" target=\"_blank\">https://dx.doi.org/10.1007/BF00212796</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Calleja, M.C.; Persoone, G.; Geladi, P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Calleja, M.C.; Persoone, G.; Geladi, P.","Englishabstract":"The acute toxicity data of the first 50 chemicals of the Multicentre Evaluation of <i>In Vitro</i> Cytotoxicity (MEIC) programme is compared for three ''cyst-based toxicity tests'' (Artoxkit M with <i><i>Artemia</i> salina</i>, Streptoxkit F with <i>Streptocephalus proboscideus</i>, and Rotoxkit F with <i>Brachionus calyciflorus</i>), and two other tests (the <i>Daphnia magna</i> and the <i>Photobacterium phosphoreum</i> Microtox(TM) tests) commonly used in ecotoxicology. The difference in sensitivity for the 50 chemicals was as high as 19 orders of magnitude (on a molecular weight basis) between the most and least sensitive species. Generally, a similar toxicity ranking of the 5 test species was found for most of the chemicals and the interspecies correlations were high. Results from principal Component Analysis (PCA) and cluster analysis indicated that the groupings are not related to a clear and defined chemical structure. However, the loading plot of the first two principal components may aid in selecting the minimum number and type of tests that have to be included in a battery which encompasses a broad spectrum of toxicity levels. Consequently, this study supports the use of a selected battery of tests to evaluate ecotoxicity and suggests its possible importance for screening of biologically-active compounds from natural sources.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Comparative acute toxicity of the first 50 Multicenter Evaluation of <i>In Vitro</i> Cytotoxicity chemicals to aquatic non-vertebrates","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-05-28 01:30:48.593348","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":"BRINE SHRIMP, FRESH-WATER, DAPHNIA-MAGNA, TEST SYSTEM, BIOASSAYS, SEEDS, METABOLITE, MYCOFLORA, ORGANISMS, TOXINS","Notes":null,"AnaPub":1994,"MonPub":null,"DateUpdate":"2001-11-28","DateCreate":"2001-06-11","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:A1994ML24900011","VABBcode":null,"OpenAcc":0,"DOI":"10.1007/BF00212796"},"refs":null,"anarec":{"AnaID":10905,"PubliDate":1994,"Pagination":"69-78","XtraPublOfAnaID":null,"ISBN":null,"Volume":"26","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":45321,"SerRR":"Archives of Environmental Contamination and Toxicology. 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