{"refrec":{"BRefID":10907,"RR":"<b>Calleja, M.C.; Persoone, G.; Geladi, P.</b> (1993). The predictive potential of a battery of ecotoxicological tests for human acute toxicity, as evaluated with first 50 MEIC chemicals. <i>ATLA. Altern. lab. anim. 21(3)</i>: 330-349","BEntID":10907,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>ATLA. Altern. lab. anim. 21(3)</i>: 330-349","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Calleja, M.C.; Persoone, G.; Geladi, P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Calleja, M.C. <i>et al.</i>","Englishabstract":"The acute toxicities of the first 50 chemicals (dextropropoxyphene hydrochloride excluded) of the multicentre evaluation of <i>in vitro</i> cytotoxicity (MEIC) programme were determined on four aquatic invertebrates and a bacterial strain (<i>Photobacterium phosphoreum</i> for the Microtox(TM) test) commonly used in ecotoxicology testing. Three of the aquatic invertebrate tests consisted of cyst-based toxicity tests (Artoxkit M with <i><i>Artemia</i> salina</i>, Streptoxkit F with <i>Streptocephalus proboscideus</i>, and Rotoxkit F with <i>Brachionus calyciflorus</i>), and the <i>Daphnia magna</i> test. Results of simple linear regression analyses indicated that the rodent tests (rat and/or mouse) were better than the ecotoxicological tests for predicting acute oral lethal doses in man. However, it appears that the batteries of ecotoxicological tests resulting from the partial least squares method appear to be better than the rodent tests for predicting human oral lethal doses.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"The predictive potential of a battery of ecotoxicological tests for human acute toxicity, as evaluated with first 50 MEIC chemicals","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Acute toxicity; human oral lethal dose; cyst-based toxicity test; ecotoxicological test; rodent test; MEIC chemicals; battery of tests; PLS method","OtherDescriptors":"ACUTE TOXICITY, HUMAN ORAL LETHAL DOSE, CYST-BASED TOXICITY TEST, ECOTOXICOLOGICAL TEST, RODENT TEST, MEIC CHEMICALS, BATTERY OF TESTS, PLS METHOD\r\nLEAST-SQUARES REGRESSION, INVITRO CYTO-TOXICITY, HELA-CELLS, DRUG TOXICITY, TETRAHYMENA-THERMOPHILA, OCULAR IRRITATION, FRESH-WATER, TEST SYSTEM, VALIDITY, MODELS","Notes":null,"AnaPub":1993,"MonPub":null,"DateUpdate":"2019-05-23","DateCreate":"2001-06-11","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":0},"refs":null,"anarec":{"AnaID":10907,"PubliDate":1993,"Pagination":"330-349","XtraPublOfAnaID":null,"ISBN":null,"Volume":"21","Issue":"3","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":45318,"SerRR":"ATLA. 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