{"refrec":{"BRefID":110013,"RR":"<b>Pedroso, M.S.; Pinho, G.L.L.; Rodrigues, S.C.; Bianchini, A.</b> (2007). Mechanism of acute silver toxicity in the euryhaline copepod <i>Acartia tonsa</i>. <i>Aquat. Toxicol. 82(3)</i>: 173-180. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2007.02.009\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2007.02.009</a>","BEntID":104698,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Aquat. Toxicol. 82(3)</i>: 173-180. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2007.02.009\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2007.02.009</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Pedroso, M.S.; Pinho, G.L.L.; Rodrigues, S.C.; Bianchini, A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Pedroso, M.S. <i>et al.</i>","Englishabstract":"Acute silver effects on whole-body ion regulation and Na<sup>+</sup>,K<sup>+</sup>-ATPase activity were evaluated in the euryhaline copepod <i>Acartia tonsa</i>. Experiments were run at 20 °C, three different salinities (5, 15 and 30 ppt), in either the absence or the presence of food (diatom <i>Thalassiosira weissflogii</i>; 2 × 10<sup>4</sup> cells/mL). Standard static-renewal procedures were used. Copepods were acutely (48 h) exposed to silver (AgNO<sub>3</sub>) concentrations equivalent to the 48-h EC10 (dissolved Ag = 3, 49, and 94 μg/L), 48-h EC30 (dissolved Ag = 5, 71, and 125 μg/L) or 48-h EC50 (dissolved Ag = 7, 83, and 173 μg/L) values in the absence of food or to the 48-h EC50 (dissolved Ag = 35, 90, and 178 μg/L) values in the presence of food. These values were previously determined under the same experimental conditions at salinities 5, 15 and 30 ppt, respectively. Endpoints analyzed were whole-body ion concentrations (Na<sup>+</sup>, Cl<sup>−</sup>, and Mg<sup>2+</sup>) and Na<sup>+</sup>,K<sup>+</sup>-ATPase activity. In starved copepods, lower whole-body Na<sup>+</sup> and Mg<sup>2+</sup> concentrations were observed in salinities 5 and 30 ppt, respectively. Also a higher whole-body Na<sup>+</sup>,K<sup>+</sup>-ATPase activity was observed in all salinities tested. Data from fed copepods indicate that all these salinity effects were completely associated with starvation. Silver exposure induced a decrease in the whole-body Mg<sup>2+</sup> concentration in starved copepods in salinities 5 and 30 ppt and a Na<sup>+</sup>,K<sup>+</sup>-ATPase inhibition in both starved and fed copepods in all salinities tested. Thus, food addition in the experimental media completely protected against silver effects on Mg<sup>2+</sup> concentration, but not against those on Na<sup>+</sup>,K<sup>+</sup>-ATPase activity. In starved copepods, enzyme inhibition was dependent on silver concentration and a relationship between this parameter and mortality was observed in all salinities tested. Therefore, Na<sup>+</sup>,K<sup>+</sup>-ATPase molecules seem to be a key site for acute silver toxicity in marine invertebrates, as reported for freshwater fish and crustaceans.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Mechanism of acute silver toxicity in the euryhaline copepod <i>Acartia tonsa</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-05-21 01:32:07.732205","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Acartia tonsa; acute toxicity; ion regulation; Na+,K+-ATPase; silver;salinity","OtherDescriptors":null,"Notes":null,"AnaPub":2007,"MonPub":null,"DateUpdate":"2020-10-22","DateCreate":"2007-04-30","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000246138800003","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.aquatox.2007.02.009"},"refs":null,"anarec":{"AnaID":110013,"PubliDate":2007,"Pagination":"173-180","XtraPublOfAnaID":null,"ISBN":null,"Volume":"82","Issue":"3","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42203,"SerRR":"Aquatic Toxicology. 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