{"refrec":{"BRefID":111188,"RR":"<b>Bringmann, G.; Lang, G.; Mühlbacher, J.; Schaumann, K.; Steffens, S.; Rytik, P.G.; Hentschel, U.; Morschhäuser, J.; Müller, W.E.G.</b> (2003). Sorbicillactone A: a structurally unprecedented bioactive novel-type alkaloid from a sponge-derived fungus, <b><i>in</i></b>: Müller, W.E.G. (Ed.) <i>Sponges (Porifera). Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology,</i> : pp. 231-253","BEntID":105833,"PublicFlag":1,"CheckedFlag":0,"wosflag":null,"vabbflag":null,"RefStringPartII":", <b><i>in</i></b>: Müller, W.E.G. (Ed.) <i>Sponges (Porifera). Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology,</i> : pp. 231-253","DocTypID":17,"DocType":"Book chapters","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Bringmann, G.; Lang, G.; Mühlbacher, J.; Schaumann, K.; Steffens, S.; Rytik, P.G.; Hentschel, U.; Morschhäuser, J.; Müller, W.E.G.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Bringmann, G. <i>et al.</i>","Englishabstract":"This chapter deals with the discovery of sorbicillactone A, as an illustrative example of the fruitful cooperation within BIOTECmarin - its isolation and chemical characterization, and its biological activities. Sorbicillactone A was isolated from a strain of <i>Penicillium chrysogenum</i> cultured from a sample of the Mediterranean sponge <i>Ircinia fasciculate</i>; it possesses a unique bicyclic lactone structure, seemingly derived from sorbicillin. Among the numerous known sorbicillin-derived structures, it is the first found to contain nitrogen and thus the first representative of a novel type of 'sorbicillin alkaloids', apparently originating from a likewise remarkable biosynthesis. Furthermore, the compound exhibits promising activities in several mammalian and viral test systems, in particular a highly selective cytostatic activity against murine leukemic lymphoblasts (L5178y) and the ability to protect human T cells against the cytopathic effects of HIV-1. These properties qualify sorbicillactone A or one of its derivatives for animal and (hopefully) also future therapeutic human trials.","AbstractOtherLang":null,"BibLvlCode":"AMS","StandardTitle":"Sorbicillactone A: a structurally unprecedented bioactive novel-type alkaloid from a sponge-derived fungus","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2003,"MonPub":null,"DateUpdate":"2007-06-20","DateCreate":"2007-06-20","SecASFANote":null,"ConfID":null,"PeerRev":0,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":0},"refs":null,"anarec":{"AnaID":111188,"PubliDate":2003,"Pagination":"231-253","XtraPublOfAnaID":null,"ISBN":"978-3-540-00968-9","Volume":null,"Issue":null,"BRefMon":111166,"BRefMonRR":"<b>Müller, W.E.G. (Ed.)</b> (2003). Sponges (Porifera). <i>Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology</i>. Springer: Berlin. ISBN 978-3-540-00968-9; e-ISBN 978-3-642-55519-0. 258 pp. <a href=\"https://dx.doi.org/10.1007/978-3-642-55519-0\" target=\"_blank\">https://dx.doi.org/10.1007/978-3-642-55519-0</a>","BRefXtra":null,"BRefXtraRR":null,"SerBRefID":111165,"SerRR":"<b>Müller, W.E.G. (Ed.)</b> Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology. Springer: Berlin.  ISSN 1611-6119","StandardTitleSer":"Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology","ISSN":"1611-6119","AbbrevSer":"Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology","StandardTitleMon":"Sponges (Porifera)","StartPage":231,"Pages":23,"ToPubliDate":null,"BRefBibLvlCode":"MS","SerNotes":null,"AutString":"Müller, W.E.G. 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