{"refrec":{"BRefID":111527,"RR":"<b>Jackson, D.J.; Macis, L.; Reitner, J.; Degnan, B.M.; Wörheide, G.</b> (2007). Sponge paleogenomics reveals an ancient role for carbonic anhydrase in skeletogenesis. <i>Science (Wash.) 316(5833)</i>: 1893-1895. <a href=\"https://dx.doi.org/10.1126/science.1141560\" target=\"_blank\">https://dx.doi.org/10.1126/science.1141560</a>","BEntID":306654,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Science (Wash.) 316(5833)</i>: 1893-1895. <a href=\"https://dx.doi.org/10.1126/science.1141560\" target=\"_blank\">https://dx.doi.org/10.1126/science.1141560</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Jackson, D.J.; Macis, L.; Reitner, J.; Degnan, B.M.; Wörheide, G.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Jackson, D.J. <i>et al.</i>","Englishabstract":"Sponges (Porifera) were prolific reef-building organisms during the Paleozoic and Mesozoic. These ancient animals inherited components of the first multicellular skeletogenic toolkit from the last common ancestor of the Metazoa (LCAM). Using a paleogenomics approach, including gene and protein expression techniques and phylogenetic reconstruction, we show that a molecular component of this toolkit was the precursor to the -carbonic anhydrases, a gene family used by extant animals in a variety of fundamental physiological processes. We used the coralline demosponge Astrosclera willeyana, a 'living fossil' that has survived from the Mesozoic, to provide insight into the evolution of the ability to biocalcify, and show that the -CA family expanded from a single ancestral gene through several independent gene duplication events in sponges and eumetazoans.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Sponge paleogenomics reveals an ancient role for carbonic anhydrase in skeletogenesis","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-23 01:32:00.205679","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2007,"MonPub":null,"DateUpdate":"2019-08-22","DateCreate":"2007-07-12","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000247602700038","VABBcode":null,"OpenAcc":0,"DOI":"10.1126/science.1141560"},"refs":null,"anarec":{"AnaID":111527,"PubliDate":2007,"Pagination":"1893-1895","XtraPublOfAnaID":null,"ISBN":null,"Volume":"316","Issue":"5833","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43776,"SerRR":"Science (Washington). 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