Document of bibliographic reference 111710

BibliographicReference record

Type
Bibliographic resource
Type of document
Book chapters
BibLvlCode
AM
Title
Biological and chemical approaches for the detection and identification of illegal estrogens in water based solutions
Abstract
Continuous production of new products used as growth promotors in animal husbandry, sports doping and products for body-building, requires residue laboratories to initiate research on developing a strategy for the identification of ‘unknown’ components. In this study, a strategy for elucidating the identity, the structure and the possible effects of illegal estrogenic compounds in an unidentified water based solution is presented. To obtain complete information on the composition and activity of the unidentified product a multi-disciplinary approach was needed. A case-study is described with a ‘solution X’ found during a raid. At first, in vivo techniques (animal trials with mice, anatomical and histological research) were combined with in vitro techniques (the yeast estrogenic screen (YES)). In a later state of the investigation, HPLC fractionation, liquid chromatography-multiple mass spectrometry (LCMS- MS) and gas chromatography-multiple mass spectrometry (GC-MS-MS) were used. Finally, the identity of ‘solution X’ was confirmed in a low concentration range (10 ng.l-1 E1 and 400 ng.l-1 EE2).
Bibliographic citation
Noppe, H.; Arijs, K.; De Wasch, K.; Van Cruchten, S.; Poelmans, S.; Courtheyn, D.; Cobbaert, E.; Gillis, W.; Vanthemsche, P.; De Brabander, H.F.; Janssen, C.R.; Van Hoof, N. (2006). Biological and chemical approaches for the detection and identification of illegal estrogens in water based solutions, in: Noppe, H. Analytiek van hormoon verstorende stoffen in milieumatrices = Analytics of endocrine disrupting chemicals in environmental matrices. pp. 59-72

Authors

author
Name
Herlinde Noppe
author
Name
Katrien Arijs
author
Name
Katia De Wasch
author
author
Name
Sofie Poelmans
author
Name
Dirk Courtheyn
author
author
author
author
author
Name
Colin Janssen
Identifier
https://orcid.org/0000-0002-7781-6679
author
Name
Nathalie Van Hoof

thesaurus terms

term
Detection (term code: 2265 - defined in term set: ASFA Thesaurus List)
Estrogens (term code: 2894 - defined in term set: ASFA Thesaurus List)
Identification (term code: 4228 - defined in term set: ASFA Thesaurus List)

Document metadata

date created
2007-07-20
date modified
2019-08-28