{"refrec":{"BRefID":111759,"RR":"<b>Soetaert, A.; Vandenbrouck, T.; Van der Ven, K.; Maras, M.; van Remortel, P.; Blust, R.; De Coen, W.M.</b> (2007). Molecular responses during cadmium-induced stress in <i>Daphnia magna</i>: integration of differential gene expression with higher-level effects. <i>Aquat. Toxicol. 83(3)</i>: 212-222. <a href=\"http://dx.doi.org/10.1016/j.aquatox.2007.04.010\" target=\"_blank\">dx.doi.org/10.1016/j.aquatox.2007.04.010</a>","BEntID":106376,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Aquat. Toxicol. 83(3)</i>: 212-222. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2007.04.010\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2007.04.010</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":1,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Soetaert, A.; Vandenbrouck, T.; Van der Ven, K.; Maras, M.; van Remortel, P.; Blust, R.; De Coen, W.M.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Soetaert, A. <i>et al.</i>","Englishabstract":"DNA microarrays offer great potential in revealing insight into mechanistic toxicity of contaminants. The aim of the present study was (i) to gain insight in concentration- and time-dependent cadmium-induced molecular responses by using a customized <i>Daphnia magna </i>microarray, and (ii) to compare the gene expression profiles with effects at higher levels of biological organization (e.g. total energy budget and growth). Daphnids were exposed to three cadmium concentrations (nominal value of 10, 50, 100 µg/l) for two time intervals (48 and 96 h). In general, dynamic expression patterns were obtained with a clear increase of gene expression changes at higher concentrations and longer exposure duration. Microarray analysis revealed cadmium affected molecular pathways associated with processes such as digestion, oxygen transport, cuticula metabolism and embryo development. These effects were compared with higher-level effects (energy budgets and growth). For instance, next to reduced energy budgets due to a decline in lipid, carbohydrate and protein content, we found an up-regulated expression of genes related to digestive processes (e.g. a-esterase, cellulase, a-amylase). 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