{"refrec":{"BRefID":113273,"RR":"<b>Kijjoa, A.; Wattanadilok, R.; Campos, N.; Nascimento, M.S.J.; Pinto, M.; Herz, W.</b> (2007). Anticancer activity evaluation of kuanoniamines A and C isolated from the marine sponge <i>Oceanapia sagittaria</i>, collected from the Gulf of Thailand. <i>Mar. Drugs 5(2)</i>: 6-22. <a href=\"https://dx.doi.org/10.3390/md502006\" target=\"_blank\">https://dx.doi.org/10.3390/md502006</a>","BEntID":107725,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Mar. Drugs 5(2)</i>: 6-22. <a href=\"https://dx.doi.org/10.3390/md502006\" target=\"_blank\">https://dx.doi.org/10.3390/md502006</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Kijjoa, A.; Wattanadilok, R.; Campos, N.; Nascimento, M.S.J.; Pinto, M.; Herz, W.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Kijjoa, A. <i>et al.</i>","Englishabstract":"The pyridoacridine alkaloids kuanoniamines A and C were isolated together with 24a-methylcholestanol, p-hydroxybenzaldehyde, p-hydroxybenzoic acid, phenylacetic acid and 3-formylindole from the ethyl acetate extract of the marine sponge <i>Oceanapia sagittaria</i> (Sollas), collected from the Gulf of Thailand. Kuanoniamines A and C were evaluated for their effect on the growth of five human tumour and a non-tumour cell lines, as well as on the proliferation of human lymphocytes. Kuanoniamine A was found to be a potent growth inhibitor of all the tumour and a non-tumour cell lines while kuanoniamine C was less potent but showed high selectivity toward the estrogen dependent (ER+) breast cancer cell line. Kuanoniamine A has shown to be a more potent inhibitor of DNA synthesis than kuanoniamine C. Kuanoniamine A was also found to cause an extensive reduction of the MCF-7 cells in G2/M phase as well as an increase in the apoptotic cells. ","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Anticancer activity evaluation of kuanoniamines A and C isolated from the marine sponge <i>Oceanapia sagittaria</i>, collected from the Gulf of Thailand","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-05-28 01:30:58.297278","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2007,"MonPub":null,"DateUpdate":"2020-10-22","DateCreate":"2007-08-27","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000247557300001","VABBcode":null,"OpenAcc":1,"DOI":"10.3390/md502006"},"refs":null,"anarec":{"AnaID":113273,"PubliDate":2007,"Pagination":"6-22","XtraPublOfAnaID":null,"ISBN":null,"Volume":"5","Issue":"2","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":113252,"SerRR":"Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel.  ISSN 1660-3397; e-ISSN 1660-3397","StandardTitleSer":"Marine Drugs","ISSN":"1660-3397","AbbrevSer":"Mar. Drugs","StandardTitleMon":null,"StartPage":6,"Pages":17,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Kijjoa","Firstname":"Anake","Initials":"A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107725,"AutID":75427,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Wattanadilok","Firstname":null,"Initials":"R.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107725,"AutID":75428,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Campos","Firstname":null,"Initials":"N.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107725,"AutID":75429,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Nascimento","Firstname":null,"Initials":"M.S.J.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107725,"AutID":75430,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Pinto","Firstname":null,"Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107725,"AutID":75431,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Herz","Firstname":null,"Initials":"W.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107725,"AutID":75432,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":353287,"LibID":36,"BRefID":113273,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"353287","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Molecular Diversity Preservation International (MDPI)","City":"Basel"}],"MONpubls":null,"pictures":[],"thestermsPath":[{"ThesaurusTerm":"Apoptosis","ThestID":53363,"Acronym":"CSA","ThesTermPath":"Apoptosis"},{"ThesaurusTerm":"Apoptosis","ThestID":113720,"Acronym":"CAB","ThesTermPath":"Necrosis > Apoptosis"}],"thestermsASFA":[{"ThesaurusTerm":"Apoptosis"},{"ThesaurusTerm":"Apoptosis"}],"taxtermsASFA":[{"TaxTerm":"Oceanapia Norman, 1869"}],"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":107725,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":107725,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.3390/md502006","externalID":"10.3390/md502006","URLTypeCode":"DOI","URLID":87101,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":[{"ThesaurusTerm":"Apoptosis","ThestID":53363,"Acronym":"CSA","ThesTypID":2,"ThesType":"CSA Technology Research Database Master Thesaurus"},{"ThesaurusTerm":"Apoptosis","ThestID":113720,"Acronym":"CAB","ThesTypID":4,"ThesType":"CAB Thesaurus"}],"taxterms":[{"TaxTerm":"Oceanapia Norman, 1869","AphiaID":131852,"TaxtID":30047}],"geoterms":null,"othterms":[{"OtherTerm":"Anticancer activity","OthtID":16869},{"OtherTerm":"Anti-proliferation of human lymphocytes","OthtID":16868},{"OtherTerm":"Cell cycle progression","OthtID":16870},{"OtherTerm":"Kuanoniamines a and c","OthtID":16871},{"OtherTerm":"Oceanapia sagittaria","OthtID":16872}],"asfacodes":null,"asfa2codes":null,"thestermsFRIS":[{"ThesaurusTerm":"Apoptosis","DutchTerm":null,"ThestID":53363,"Acronym":"CSA","ThesTypID":2,"ThesType":"CSA Technology Research Database Master Thesaurus"},{"ThesaurusTerm":"Apoptosis","DutchTerm":null,"ThestID":113720,"Acronym":"CAB","ThesTypID":4,"ThesType":"CAB Thesaurus"}],"taxtermsFRIS":[{"TaxTerm":"Oceanapia Norman, 1869","DutchTerm":null,"AphiaID":131852,"TaxtID":30047}],"geotermsFRIS":null,"othtermsFRIS":[{"OtherTerm":"Anticancer activity","DutchTerm":null,"OthtID":16869},{"OtherTerm":"Anti-proliferation of human lymphocytes","DutchTerm":null,"OthtID":16868},{"OtherTerm":"Cell cycle progression","DutchTerm":null,"OthtID":16870},{"OtherTerm":"Kuanoniamines a and c","DutchTerm":null,"OthtID":16871},{"OtherTerm":"Oceanapia sagittaria","DutchTerm":null,"OthtID":16872}],"resmessage":"","complete":1,"sessions":{"newSesName":"Haspeslagh, Jan, J.","newSesDate":{"date":"2007-08-27 09:15:01.593000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2020-10-22 06:53:58.010000","timezone_type":3,"timezone":"Europe/Brussels"}}}