{"refrec":{"BRefID":113283,"RR":"<b>De Oliveira, J.H.H.L.; Seleghim, M.H.R.; Timm, C.; Grube, A.; Köck, M.; Nascimento, G.G.F.; Martins, A.C.T.; Silva, E.G.O.; De Souza, A.O.; Minarini, P.R.R.; Galetti, F.C.S.; Silva, C.L.; Hajdu, E.; Berlinck, R.G.S.</b> (2006). Antimicrobial and antimycobacterial activity of cyclostellettamine alkaloids from sponge <i>Pachychalina</i> sp. <i>Mar. Drugs 4(1)</i>: 1-8. <a href=\"https://dx.doi.org/10.3390/md401001\" target=\"_blank\">https://dx.doi.org/10.3390/md401001</a>","BEntID":107736,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":" <i>Mar. Drugs 4(1)</i>: 1-8. <a href=\"https://dx.doi.org/10.3390/md401001\" target=\"_blank\">https://dx.doi.org/10.3390/md401001</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"De Oliveira, J.H.H.L.; Seleghim, M.H.R.; Timm, C.; Grube, A.; Köck, M.; Nascimento, G.G.F.; Martins, A.C.T.; Silva, E.G.O.; De Souza, A.O.; Minarini, P.R.R.; Galetti, F.C.S.; Silva, C.L.; Hajdu, E.; Berlinck, R.G.S.","OrigTitleTranslFlag":0,"Authorstringtrunc":"De Oliveira, J.H.H.L. <i>et al.</i>","Englishabstract":"Cyclostellettamines A - F (1 - 6) isolated from the sponge <i>Pachychalina</i> sp. and cyclostellettamines G - I, K and L (7 - 11) obtained by synthesis were evaluated in bioassays of antimicrobial activity against susceptible and antibiotic-resistant <i>Staphylococcus aureus, Pseudomonas aeruginosa</i> and antibiotic-susceptible <i>Escherichia coli</i> and <i>Candida albicans</i>, as well as in antimycobacterial activity against <i>Mycobacterium tuberculosis</i> H37Rv bioassays. The results obtained indicated that cyclostellettamines display different antimicrobial activity depending on the alkyl-chain size, suggesting that, if a mechanism-of action is implied, it is dependent on the distance between the two pyridinium moieties of cyclostellettamines. ","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Antimicrobial and antimycobacterial activity of cyclostellettamine alkaloids from sponge <i>Pachychalina</i> sp.","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-05-27 01:31:00.798205","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2006,"MonPub":null,"DateUpdate":"2020-10-22","DateCreate":"2007-08-27","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000241342700001","VABBcode":null,"OpenAcc":1,"DOI":"10.3390/md401001"},"refs":null,"anarec":{"AnaID":113283,"PubliDate":2006,"Pagination":"1-8","XtraPublOfAnaID":null,"ISBN":null,"Volume":"4","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":113252,"SerRR":"Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel.  ISSN 1660-3397; e-ISSN 1660-3397","StandardTitleSer":"Marine Drugs","ISSN":"1660-3397","AbbrevSer":"Mar. Drugs","StandardTitleMon":null,"StartPage":1,"Pages":8,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"De Oliveira","Firstname":null,"Initials":"J.H.H.L.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107736,"AutID":75447,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Seleghim","Firstname":null,"Initials":"M.H.R.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107736,"AutID":75448,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Timm","Firstname":null,"Initials":"C.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107736,"AutID":75449,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Grube","Firstname":null,"Initials":"A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107736,"AutID":75450,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Köck","Firstname":null,"Initials":"M.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107736,"AutID":75451,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Nascimento","Firstname":null,"Initials":"G.G.F.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107736,"AutID":75452,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Martins","Firstname":null,"Initials":"A.C.T.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107736,"AutID":75453,"OrderNr":7,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Silva","Firstname":null,"Initials":"E.G.O.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107736,"AutID":75454,"OrderNr":8,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"De Souza","Firstname":null,"Initials":"A.O.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107736,"AutID":75455,"OrderNr":9,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Minarini","Firstname":null,"Initials":"P.R.R.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107736,"AutID":75456,"OrderNr":10,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Galetti","Firstname":null,"Initials":"F.C.S.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107736,"AutID":75457,"OrderNr":11,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Silva","Firstname":null,"Initials":"C.L.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107736,"AutID":75458,"OrderNr":12,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Hajdu","Firstname":"Eduardo","Initials":"E.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107736,"AutID":1857,"OrderNr":13,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Berlinck","Firstname":null,"Initials":"R.G.S.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107736,"AutID":75459,"OrderNr":14,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":353291,"LibID":36,"BRefID":113283,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"353291","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Molecular Diversity Preservation International (MDPI)","City":"Basel"}],"MONpubls":null,"pictures":[],"thestermsPath":[{"ThesaurusTerm":"Antibacterials","ThestID":438,"Acronym":"ASFA","ThesTermPath":"Antibacterials"},{"ThesaurusTerm":"Alkaloids","ThestID":285,"Acronym":"ASFA","ThesTermPath":"Chemical compounds > Organic compounds > Alkaloids"},{"ThesaurusTerm":"Antibiotics","ThestID":440,"Acronym":"ASFA","ThesTermPath":"Drugs > Antibiotics"},{"ThesaurusTerm":"Pseudomonas aeruginosa","ThestID":160216,"Acronym":"CAB","ThesTermPath":"Prokaryotes > Microorganisms > Bacteria > Gracilicutes > Pseudomonadaceae > Pseudomonas > Pseudomonas aeruginosa"},{"ThesaurusTerm":"Pseudomonas aeruginosa","ThestID":89242,"Acronym":"CSA","ThesTermPath":"Pseudomonas aeruginosa"}],"thestermsASFA":[{"ThesaurusTerm":"Alkaloids"},{"ThesaurusTerm":"Antibiotics"},{"ThesaurusTerm":"Pseudomonas aeruginosa"},{"ThesaurusTerm":"Pseudomonas aeruginosa"}],"taxtermsASFA":[{"TaxTerm":"Candida albicans"},{"TaxTerm":"Escherichia coli"},{"TaxTerm":"Mycobacterium tuberculosis"},{"TaxTerm":"Porifera"},{"TaxTerm":"Pseudomonas aeruginosa"},{"TaxTerm":"Staphylococcus aureus"}],"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":107736,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":107736,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.3390/md401001","externalID":"10.3390/md401001","URLTypeCode":"DOI","URLID":87105,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":[{"ThesaurusTerm":"Alkaloids","ThestID":285,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Antibacterials","ThestID":438,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Antibiotics","ThestID":440,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Pseudomonas aeruginosa","ThestID":89242,"Acronym":"CSA","ThesTypID":2,"ThesType":"CSA Technology Research Database Master Thesaurus"},{"ThesaurusTerm":"Pseudomonas aeruginosa","ThestID":160216,"Acronym":"CAB","ThesTypID":4,"ThesType":"CAB Thesaurus"}],"taxterms":[{"TaxTerm":"Candida albicans","AphiaID":null,"TaxtID":36493},{"TaxTerm":"Escherichia coli","AphiaID":422817,"TaxtID":23081},{"TaxTerm":"Mycobacterium tuberculosis","AphiaID":null,"TaxtID":36494},{"TaxTerm":"Porifera [Sponges]","AphiaID":558,"TaxtID":18378},{"TaxTerm":"Pseudomonas aeruginosa","AphiaID":null,"TaxtID":36495},{"TaxTerm":"Staphylococcus aureus","AphiaID":null,"TaxtID":36028}],"geoterms":null,"othterms":[{"OtherTerm":"Cyclostellettamine","OthtID":16883},{"OtherTerm":"Pachychalina","OthtID":16884}],"asfacodes":null,"asfa2codes":null,"thestermsFRIS":[{"ThesaurusTerm":"Alkaloids","DutchTerm":null,"ThestID":285,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Antibacterials","DutchTerm":null,"ThestID":438,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Antibiotics","DutchTerm":null,"ThestID":440,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Pseudomonas aeruginosa","DutchTerm":null,"ThestID":89242,"Acronym":"CSA","ThesTypID":2,"ThesType":"CSA Technology Research Database Master Thesaurus"},{"ThesaurusTerm":"Pseudomonas aeruginosa","DutchTerm":null,"ThestID":160216,"Acronym":"CAB","ThesTypID":4,"ThesType":"CAB Thesaurus"}],"taxtermsFRIS":[{"TaxTerm":"Candida albicans","DutchTerm":null,"AphiaID":null,"TaxtID":36493},{"TaxTerm":"Escherichia coli","DutchTerm":null,"AphiaID":422817,"TaxtID":23081},{"TaxTerm":"Mycobacterium tuberculosis","DutchTerm":null,"AphiaID":null,"TaxtID":36494},{"TaxTerm":"Porifera","DutchTerm":"Sponzen","AphiaID":558,"TaxtID":18378},{"TaxTerm":"Pseudomonas aeruginosa","DutchTerm":null,"AphiaID":null,"TaxtID":36495},{"TaxTerm":"Staphylococcus aureus","DutchTerm":null,"AphiaID":null,"TaxtID":36028}],"geotermsFRIS":null,"othtermsFRIS":[{"OtherTerm":"Cyclostellettamine","DutchTerm":null,"OthtID":16883},{"OtherTerm":"Pachychalina","DutchTerm":null,"OthtID":16884}],"resmessage":"","complete":1,"sessions":{"newSesName":"Haspeslagh, Jan, J.","newSesDate":{"date":"2007-08-27 09:15:01.593000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2020-10-22 06:53:58.010000","timezone_type":3,"timezone":"Europe/Brussels"}}}