{"refrec":{"BRefID":113288,"RR":"<b>Oda, T.; Fujiwara, T.; Liu, H.; Ukai, K.; Mangindaan, R.E.P.; Mochizuki, M.; Namikoshi, M.</b> (2006). Effects of lissoclibadins and lissoclinotoxins, isolated from a tropical ascidian <i>Lissoclinum</i> cf. <i>badium</i>, on IL-8 production in a PMA-stimulated promyelocytic leukemia cell line. <i>Mar. Drugs 4(1)</i>: 15-21. <a href=\"https://dx.doi.org/10.3390/md401015\" target=\"_blank\">https://dx.doi.org/10.3390/md401015</a>","BEntID":107740,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Mar. Drugs 4(1)</i>: 15-21. <a href=\"https://dx.doi.org/10.3390/md401015\" target=\"_blank\">https://dx.doi.org/10.3390/md401015</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Oda, T.; Fujiwara, T.; Liu, H.; Ukai, K.; Mangindaan, R.E.P.; Mochizuki, M.; Namikoshi, M.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Oda, T. <i>et al.</i>","Englishabstract":"The effects of seven compounds 1-7, isolated from a tropical ascidian <i>Lissoclinum</i> cf. <i>badium</i>, on IL-8 production in PMA-stimulated HL-60 cells were examined. Lissoclibadins 2 (2) and 3 (3) and lissoclinotoxin F (5) increased the IL-8 production in a dose-dependent manner. Compounds 2 and 5 are structural isomers possessing dimeric structures of trans and cis-orientations, respectively, and showed a very similar activity on the induction of IL-8 levels. Compound 3 and lissoclinotoxin E (4) are also structural isomers having dimeric trans and cis-structures, respectively, but 4 did not induce the IL-8 production. Lissoclibadin 1 (1, trimeric compound) and two monomeric compounds (6 and 7) did not increase the IL-8 level. Therefore, the differences in their structures remarkably affected the IL-8 production activity, the inhibition of cell proliferation, and the survival of HL-60 cells. Lissoclibadin 2 was the most interesting compound of the seven metabolites tested in this study. 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