{"refrec":{"BRefID":113307,"RR":"<b>Geffeney, S.L.; Ruben, P.C.</b> (2006). The structural basis and functional consequences of interactions between tetrodotoxin and voltage-gated sodium channels. <i>Mar. Drugs 4(3)</i>: 143-156. <a href=\"https://dx.doi.org/10.3390/md403143\" target=\"_blank\">https://dx.doi.org/10.3390/md403143</a>","BEntID":107760,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Mar. Drugs 4(3)</i>: 143-156. <a href=\"https://dx.doi.org/10.3390/md403143\" target=\"_blank\">https://dx.doi.org/10.3390/md403143</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Geffeney, S.L.; Ruben, P.C.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Geffeney, S.L.; Ruben, P.C.","Englishabstract":"Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms. Until recently, channel resistance was thought to be primarily imparted by amino acid substitutions at a single position in domain I. Recent work reveals a novel site for tetrodotoxin resistance in the P-region of domain IV. ","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"The structural basis and functional consequences of interactions between tetrodotoxin and voltage-gated sodium channels","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-02 01:31:12.799503","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2006,"MonPub":null,"DateUpdate":"2020-10-23","DateCreate":"2007-08-27","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000241343000005","VABBcode":null,"OpenAcc":1,"DOI":"10.3390/md403143"},"refs":null,"anarec":{"AnaID":113307,"PubliDate":2006,"Pagination":"143-156","XtraPublOfAnaID":null,"ISBN":null,"Volume":"4","Issue":"3","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":113252,"SerRR":"Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel.  ISSN 1660-3397; e-ISSN 1660-3397","StandardTitleSer":"Marine Drugs","ISSN":"1660-3397","AbbrevSer":"Mar. Drugs","StandardTitleMon":null,"StartPage":143,"Pages":14,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Geffeney","Firstname":null,"Initials":"S.L.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107760,"AutID":75490,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Ruben","Firstname":null,"Initials":"P.C.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":107760,"AutID":75491,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":353298,"LibID":36,"BRefID":113307,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"353298","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Molecular Diversity Preservation International (MDPI)","City":"Basel"}],"MONpubls":null,"pictures":[],"thestermsPath":[{"ThesaurusTerm":"Neurotoxins","ThestID":5534,"Acronym":"ASFA","ThesTermPath":"Materials > Hazardous materials > Biological poisons > Neurotoxins"},{"ThesaurusTerm":"Tetrodotoxin","ThestID":8474,"Acronym":"ASFA","ThesTermPath":"Materials > Hazardous materials > Biological poisons > Tetrodotoxin"},{"ThesaurusTerm":"TTX","ThestID":77098,"Acronym":"CSA","ThesTermPath":"TTX"}],"thestermsASFA":[{"ThesaurusTerm":"Neurotoxins"},{"ThesaurusTerm":"Tetrodotoxin"},{"ThesaurusTerm":"TTX"}],"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":107760,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":107760,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.3390/md403143","externalID":"10.3390/md403143","URLTypeCode":"DOI","URLID":87114,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":[{"ThesaurusTerm":"Neurotoxins","ThestID":5534,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Tetrodotoxin","ThestID":8474,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"TTX","ThestID":77098,"Acronym":"CSA","ThesTypID":2,"ThesType":"CSA Technology Research Database Master Thesaurus"}],"taxterms":null,"geoterms":null,"othterms":[{"OtherTerm":"Inward sodium current","OthtID":16914},{"OtherTerm":"Voltage clamp","OthtID":16916}],"asfacodes":null,"asfa2codes":null,"thestermsFRIS":[{"ThesaurusTerm":"Neurotoxins","DutchTerm":null,"ThestID":5534,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Tetrodotoxin","DutchTerm":null,"ThestID":8474,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"TTX","DutchTerm":null,"ThestID":77098,"Acronym":"CSA","ThesTypID":2,"ThesType":"CSA Technology Research Database Master Thesaurus"}],"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":[{"OtherTerm":"Inward sodium current","DutchTerm":null,"OthtID":16914},{"OtherTerm":"Voltage clamp","DutchTerm":null,"OthtID":16916}],"resmessage":"","complete":1,"sessions":{"newSesName":"Haspeslagh, Jan, J.","newSesDate":{"date":"2007-08-27 09:15:01.593000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2020-10-23 07:01:24.213000","timezone_type":3,"timezone":"Europe/Brussels"}}}