{"refrec":{"BRefID":113312,"RR":"<b>Schroeder, C.I.; Lewis, R.J.</b> (2006). ω-conotoxins GVIA, MVIIA and CVID: SAR and clinical potential. <i>Mar. Drugs 4(3)</i>: 193-214","BEntID":107765,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Mar. Drugs 4(3)</i>: 193-214","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Schroeder, C.I.; Lewis, R.J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Schroeder, C.I.; Lewis, R.J.","Englishabstract":"Highly selective N-type voltage-gated calcium (CaV) channel inhibitors from cone snail venom (the ω-conotoxins) have emerged as a new class of therapeutics for the treatment of chronic and neuropathic pain. Earlier in 2005, Prialt (Elan) or synthetic ω-conotoxin MVIIA, was the first ω-conotoxin to be approved by Food and Drug Administration for human use. This review compares the action of three ω-conotoxins, GVIA, MVIIA and CVID, describing their structure-activity relationships and potential as leads for the design of improved N-type therapeutics that are more useful in the treatment of chronic pain. 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