{"refrec":{"BRefID":113314,"RR":"<b>Wen, L.; Yang, S.; Zhou, W.; Zhang, Y.; Huang, P.</b> (2006). New conotoxin SO-3 targeting N-type voltage-sensitive calcium channels. <i>Mar. Drugs 4(3)</i>: 215-227. <a href=\"https://dx.doi.org/10.3390/md403215\" target=\"_blank\">https://dx.doi.org/10.3390/md403215</a>","BEntID":107769,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Mar. Drugs 4(3)</i>: 215-227. <a href=\"https://dx.doi.org/10.3390/md403215\" target=\"_blank\">https://dx.doi.org/10.3390/md403215</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Wen, L.; Yang, S.; Zhou, W.; Zhang, Y.; Huang, P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Wen, L. <i>et al.</i>","Englishabstract":"Selective blockers of the N-type voltage-sensitive calcium (CaV) channels are useful in the management of severe chronic pain. Here, the structure and function characteristics of a novel N-type CaV channel blocker, SO-3, are reviewed. SO-3 is a 25-amino acid conopeptide originally derived from the venom of <i>Conus striatus</i>, and contains the same 4-loop, 6-cysteine framework (C-C-CC-C-C) as O-superfamily conotoxins. The synthetic SO-3 has high analgesic activity similar to ω-conotoxin MVIIA (MVIIA), a selective N-type CaV channel blocker approved in the USA and Europe for the alleviation of persistent pain states. In electrophysiological studies, SO-3 shows more selectivity towards the N-type CaV channels than MVIIA. The dissimilarity between SO-3 and MVIIA in the primary and tertiary structures is further discussed in an attempt to illustrate the difference in selectivity of SO-3 and MVIIA towards N-type CaV channels. 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