{"refrec":{"BRefID":113320,"RR":"<b>Kem, W.; Soti, F.; Wildeboer, K.; LeFrancois, S.; MacDougall, K.; Wei, D.-Q.; Chou, K.-C.; Arias, H.R.</b> (2006). The nemertine toxin anabaseine and its derivative DMXBA (GTS-21): chemical and pharmacological properties. <i>Mar. Drugs 4(3)</i>: 255-273. <a href=\"https://dx.doi.org/10.3390/md403255\" target=\"_blank\">https://dx.doi.org/10.3390/md403255</a>","BEntID":107773,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Mar. Drugs 4(3)</i>: 255-273. <a href=\"https://dx.doi.org/10.3390/md403255\" target=\"_blank\">https://dx.doi.org/10.3390/md403255</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Kem, W.; Soti, F.; Wildeboer, K.; LeFrancois, S.; MacDougall, K.; Wei, D.-Q.; Chou, K.-C.; Arias, H.R.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Kem, W. <i>et al.</i>","Englishabstract":"Nemertines are a phylum of carnivorous marine worms that possess a variety of alkaloidal, peptidic or proteinaceous toxins that serve as chemical defenses against potential predators. The hoplonemertines additionally envenomate their prey with a mixture of proboscis alkaloids delivered with the help of a calcareous stylet that punctures the skin of the victim. Anabaseine, the first of these alkaloids to be identified, stimulates a wide variety of animal nicotinic acetylcholine receptors (AChRs), especially the neuromuscular AChRs that are inhibited by the snake peptide a-bungarotoxin. A synthetic derivative, 3-(2,4-Dimethoxybenzylidene)-Anabaseine (DMXBA; also called GTS-21), improves memory in experimental animals and humans and is currently in clinical trials to determine whether it can ameliorate cognitive problems associated with schizophrenia. Here we summarize present knowledge concerning the chemistry and mechanisms of action of these two substances (anabaseine and DMXBA) on AChRs, especially those found in the mammalian brain. 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