{"refrec":{"BRefID":117342,"RR":"<b>Karawita, R.; Senevirathne, M.; Athukorala, Y.; Affan, A.; Lee, Y.J.; Kim, S.-K.; Lee, J.-B.; Jeon, Y.-J.</b> (2007). Protective effect of enzymatic extracts from microalgae against DNA damage induced by H<sub>2</sub>O<sub>2</sub>. <i>Mar. Biotechnol. 9(4)</i>: 479-490. <a href=\"https://dx.doi.org/10.1007/s10126-007-9007-3\" target=\"_blank\">https://dx.doi.org/10.1007/s10126-007-9007-3</a>","BEntID":111655,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Mar. Biotechnol. 9(4)</i>: 479-490. <a href=\"https://dx.doi.org/10.1007/s10126-007-9007-3\" target=\"_blank\">https://dx.doi.org/10.1007/s10126-007-9007-3</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Karawita, R.; Senevirathne, M.; Athukorala, Y.; Affan, A.; Lee, Y.J.; Kim, S.-K.; Lee, J.-B.; Jeon, Y.-J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Karawita, R. <i>et al.</i>","Englishabstract":"The enzymatic extracts from seven species of microalgae (<i>Pediastrum duplex, Dactylococcopsis fascicularis, Halochlorococcum porphyrae, Oltmannsiellopsis unicellularis, Achnanthes longipes</i>, <i>Navicula</i> sp. and <i>Amphora coffeaeformis</i>) collected from three habitats (freshwater, tidal pool, and coastal benthic) at Jeju Island in Korea were investigated for their antioxidant activity. Of the extracts tested, the AMG 300 L (an exo 1, 4-α-d-glucosidase) extract of <i>P. duplex</i>, the Viscozyme extract of Navicula sp., and the Celluclast extract of A. longipes provided the most potential as antioxidants. Meanwhile, the Termamyl extract of <i>P. duplex</i> in an H<sub>2</sub>O<sub>2</sub> scavenging assay exhibited an approximate 60% scavenging effect. In this study, we report that the DNA damage inhibitory effects of <i>P. duplex</i> (Termamyl extract) and <i>D. fascicularis</i> (Kojizyme extract) were nearly 80% and 69% respectively at a concentration of 100 µg/ml. Thus, it is suggested that the microalgae tested in this study yield promising DNA damage inhibitory properties on mouse lymphoma L 5178 cells that are treated with H<sub>2</sub>O<sub>2</sub>. Therefore, microalgae such as <i>P. duplex</i> may be an excellent source of naturally occurring antioxidant compounds with potent DNA damage inhibition potential. 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