{"refrec":{"BRefID":119965,"RR":"<b>van Rijssel, M.; Alderkamp, A.-C.; Nejstgaard, J.C.; Sazhin, A.F.; Verity, P.G.</b> (2007). Haemolytic activity of live <i>Phaeocystis pouchetii</i> during mesocosm blooms. <i>Biogeochemistry 83(1-3)</i>: 189-200. <a href=\"https://dx.doi.org/10.1007/s10533-007-9095-1\" target=\"_blank\">https://dx.doi.org/10.1007/s10533-007-9095-1</a>","BEntID":114182,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Biogeochemistry 83(1-3)</i>: 189-200. <a href=\"https://dx.doi.org/10.1007/s10533-007-9095-1\" target=\"_blank\">https://dx.doi.org/10.1007/s10533-007-9095-1</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"van Rijssel, M.; Alderkamp, A.-C.; Nejstgaard, J.C.; Sazhin, A.F.; Verity, P.G.","OrigTitleTranslFlag":0,"Authorstringtrunc":"van Rijssel, M. <i>et al.</i>","Englishabstract":"Chemical defence is a potential mechanism contributing to the success of <i>Phaeocystis</i> species that repeatedly dominate the phytoplankton in coastal areas. Species within the genus <i>Phaeocystis</i> have long been suspected of imposing negative effects on co-occurring organisms. Recently a number of toxins have been extracted and identified from <i>Phaeocystis</i> samples, but it is not clear if they do enhance the competitive advantage of <i>Phaeocystis</i> species. In the present study the cytotoxic impact of live <i>Phaeocystis pouchetii</i> to human blood cells in close proximity, regardless of the nature of the responsible mechanism, was quantified using a bioassay. Haemolytic activity was measured during blooms of <i>P. pouchetii</i> in mesocosms. These environments were chosen to mimic natural conditions including chemically mediated interactions that could trigger defensive and/or allelopathic responses of <i>Phaeocystis</i>. Haemolytic activity correlated with <i>P. pouchetii</i> numbers and was absent during the preceding diatom bloom. Samples containing live <i>P. pouchetii</i> cells showed the highest activity, while filtered sea water and cell extracts were less haemolytic or without effect. Dose-response curves were linear up to 70% lysis, and haemolysis in samples containing live <i>P. pouchetii</i> cells reached EC<sub>50</sub> values comparable to known toxic prymnesiophytes (1.9*10<sup>7</sup> cells l <sup>-1</sup>). Haemolytic activity was enhanced by increased temperature and light. The results indicate that unprotected and thus presumably vulnerable cells present in a <i>P. pouchetii</i> bloom may lyse within days. ","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Haemolytic activity of live <i>Phaeocystis pouchetii</i> during mesocosm blooms","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2025-01-28 08:31:40.333000","timezone_type":1,"timezone":"+00:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"allelopathy; Chemical defence; prymnesiophyte; PUFA; PUA","OtherDescriptors":null,"Notes":null,"AnaPub":2007,"MonPub":null,"DateUpdate":"2021-02-23","DateCreate":"2008-02-20","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000246561700014","VABBcode":null,"OpenAcc":1,"DOI":"10.1007/s10533-007-9095-1"},"refs":null,"anarec":{"AnaID":119965,"PubliDate":2007,"Pagination":"189-200","XtraPublOfAnaID":null,"ISBN":null,"Volume":"83","Issue":"1-3","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":45092,"SerRR":"Biogeochemistry. Springer: Dordrecht; Lancaster; Boston.  ISSN 0168-2563; e-ISSN 1573-515X","StandardTitleSer":"Biogeochemistry","ISSN":"0168-2563","AbbrevSer":"Biogeochemistry","StandardTitleMon":null,"StartPage":189,"Pages":12,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":[{"YBRefID":120024,"RefStrFull":"<b>Van Leeuwe, M.A.; Stefels, J.; Belviso, S.; Lancelot, C.; Verity, P.G.; Gieskes, W.W.C. (Ed.)</b> (2007). <i>Phaeocystis</i>, major link in the biogeochemical cycling of climate-relevant elements. <i>Biogeochemistry</i>, 83(1-3). Springer: Dordrecht. 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