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Cytochemical threshold concns are comparable to known environmental levels and are about 1 order of magnitude lower than those obtained by measuring colony growth rates. Pretreatment of colonies with Cu<sup>2+</sup> gave no indication of tolerance adaptation, although there is evidence of the cumulative toxicity of Cu<sup>2+</sup>  and the possible sequestration of this metal in endodermal cell lysosomes. 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