{"refrec":{"BRefID":121608,"RR":"<b>Bosmans, F.; Aneiros, A.; Tytgat, J.</b> (2002). The sea anemone <i>Bunodosoma granulifera</i> contains surprisingly efficacious and potent insect-selective toxins. <i>FEBS Lett. 532(1-2)</i>: 131-134. <a href=\"http://dx.doi.org/10.1016/S0014-5793(02)03653-0\" target=\"_blank\">dx.doi.org/10.1016/S0014-5793(02)03653-0</a>","BEntID":115701,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>FEBS Lett. 532(1-2)</i>: 131-134. <a href=\"https://dx.doi.org/10.1016/S0014-5793(02)03653-0\" target=\"_blank\">https://dx.doi.org/10.1016/S0014-5793(02)03653-0</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Bosmans, F.; Aneiros, A.; Tytgat, J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Bosmans, F. <i>et al.</i>","Englishabstract":"Two sodium channel toxins, <i>Bg</i>II and <i>Bg</i>III, isolated from the sea anemone <i>Bunodosoma granulifera</i>, have been subjected to an elaborate electrophysiological and pharmacological comparison between five different cloned sodium channels expressed in <i>Xenopus laevis</i> oocytes in order to determine their efficacy, potency and selectivity. Our results reveal large differences in toxin-induced effect between the different sodium channels. These toxins possess the highest efficacy for the insect sodium channel (para). Our data also show that <i>Bg</i>II, generally known as a neurotoxin, is especially potent on the insect sodium channel with an EC<sub>50</sub> value of 5.5±0.5 nM. Therefore, this toxin can be used as a template for further development of new insecticides. Based on our findings, an evolutionary relationship between crustaceans and insects is also discussed. 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