Document of bibliographic reference 128110

BibliographicReference record

Type
Bibliographic resource
Type of document
Journal article
BibLvlCode
AS
Title
Derivation of an aquatic predicted no-effect concentration for the synthetic hormone, 17a-ethinyl estradiol
Abstract
17a-Ethinyl estradiol (EE2) is a synthetic estrogen widely used in combination with othersteroid hormones in oral contraceptives and in the contraceptive patch. EE2 has been detected in sewage treatment plant effluents in the low nanogram -per-liter range and occasionally in surface waters in the U.S., U.K., Canada, Brazil, Germany, and elsewhere. The mode of action is receptor-mediated, and estrogen receptors exist in mammals and other vertebrates. A large number of studies on the effects of EE2 on aquatic organisms exist. One hundred English language studies published between 1994 and 2007, one as yet unpublished study, and findings published in conference proceedings (in German) were compared to published data quality criteria to identify the most relevant studies for deriving a predicted no-effect concentration (PNEC). Reproduction in fish was identified as the most sensitive end point in aquatic species. A species sensitivity distribution was constructed using no observed effect concentrations (NOECs) for reproductive effects from 39 papers in 26 species, resulting in a median hazardous concentration at which 5% of the species tested are affected (HC5,50) of 0.35 ng/L. After comparing this HC5,50 to all of the laboratory and field-derived toxicity information available for EE2, we recommend using 0.35 ng/L as the PNEC for EE2 in surface water. This PNEC is below 95% of the existing NOECs for effects on reproduction and is also below virtually all of the NOECs for vitellogenin induction in the key fish reproduction studies.
WebOfScience code
https://www.webofscience.com/wos/woscc/full-record/WOS:000259603700008
Bibliographic citation
Caldwell, D.J.; Mastrocco, F.; Hutchinson, T.H.; Länge, R.; Heijerick, D.; Janssen, C.; Anderson, P.D.; Sumpter, J.P. (2008). Derivation of an aquatic predicted no-effect concentration for the synthetic hormone, 17a-ethinyl estradiol. Environ. Sci. Technol. 42(19): 7046-7054. dx.doi.org/10.1021/es800633q
Topic
Marine
Fresh water
Is peer reviewed
true

Authors

author
Name
Daniel Caldwell
author
Name
Frank Mastrocco
author
Name
Thomas Hutchinson
author
author
Name
Dagobert Heijerick
Affiliation
European Centre for Risk Assessment bvba
author
Name
Colin Janssen
Identifier
https://orcid.org/0000-0002-7781-6679
Affiliation
Universiteit Gent
author
Name
Paul Anderson
author
Name
John Sumpter

Links

referenced creativework
type
DOI
accessURL
https://dx.doi.org/10.1021/es800633q

thesaurus terms

term
Aquaculture (term code: 473 - defined in term set: ASFA Thesaurus List)
Aquatic organisms (term code: 514 - defined in term set: ASFA Thesaurus List)
Concentration (composition) (term code: 85482 - defined in term set: CSA Technology Research Database Master Thesaurus)
Data quality (term code: 102124 - defined in term set: Transportation Research Thesaurus)
Effluents (term code: 9792 - defined in term set: ASFA Thesaurus List)
Estradiol (term code: 136772 - defined in term set: CAB Thesaurus)
Estrogens (term code: 2894 - defined in term set: ASFA Thesaurus List)
Ethinylestradiol (term code: 136805 - defined in term set: CAB Thesaurus)
Forecasting (term code: 3418 - defined in term set: ASFA Thesaurus List)
Mammals (aquatic) (term code: 4938 - defined in term set: ASFA Thesaurus List)
Mode of action (term code: 134096 - defined in term set: CAB Thesaurus)
Pollution effects (term code: 6392 - defined in term set: ASFA Thesaurus List)
Reproduction (term code: 6879 - defined in term set: ASFA Thesaurus List)
Sewage (term code: 7510 - defined in term set: ASFA Thesaurus List)
Sewage treatment (term code: 7518 - defined in term set: ASFA Thesaurus List)
Surface water (term code: 8244 - defined in term set: ASFA Thesaurus List)

taxonomic terms

taxonomic terms associated with this publication
Mammalia [mammals]
Vertebrata [vertebrates]

Document metadata

date created
2008-12-11
date modified
2018-05-17