{"refrec":{"BRefID":128638,"RR":"<b>De Schamphelaere, K.A.C.; Heijerick, D.G.; Janssen, C.R.<\/b> (2006). Cross-phylum comparison of a chronic biotic ligand model to predict chronic toxicity of copper to a freshwater rotifer, <i>Brachionus calyciflorus<\/i> (Pallas). <i>Ecotoxicol. Environ. Saf. 63(2)<\/i>: 189-195. <a href=\"https:\/\/dx.doi.org\/10.1016\/j.ecoenv.2005.07.012\" target=\"_blank\">https:\/\/dx.doi.org\/10.1016\/j.ecoenv.2005.07.012<\/a>","BEntID":122728,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Ecotoxicol. Environ. Saf. 63(2)<\/i>: 189-195. <a href=\"https:\/\/dx.doi.org\/10.1016\/j.ecoenv.2005.07.012\" target=\"_blank\">https:\/\/dx.doi.org\/10.1016\/j.ecoenv.2005.07.012<\/a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":1,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"De Schamphelaere, K.A.C.; Heijerick, D.G.; Janssen, C.R.","OrigTitleTranslFlag":0,"Authorstringtrunc":"De Schamphelaere, K.A.C.; Heijerick, D.G.; Janssen, C.R.","Englishabstract":"Short chronic 48-h toxicity tests with the freshwater rotifer <i>Brachionus calyciflorus<\/i> (Pallas) were conducted to assess the modifying effects of pH and natural dissolved organic carbon (DOC) concentration on reproductive toxicity of Cu. Toxicity tests were carried out in four test waters according to a 2 x 2 design, in which pH (6 and 7.8) and DOC (5 and 15 mgC\/L) were the test variables. Concentrations of dissolved Cu with no observed effect at 48 h (NOEC) varied 12-fold between 8.2 and 103 \u03bcg\/L. Higher DOC and higher pH resulted in a reduction of toxicity, which is in line with the concepts of the biotic ligand model (BLM). A chronic Cu-BLM, originally developed for the cladoceran <i>Daphnia magna<\/i>, was calibrated to the rotifer dataset and was found to be able to predict all rotifer NOECs with an error factor of less than 1.6. 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