{"refrec":{"BRefID":131644,"RR":"<b>Regalado, E.L.; Rodríguez, M.; Menéndez, R.; Concepción, Á.A.; Nogueiras, C.; Laguna, A.; Rodríguez, A.A.; Williams, D.E.; Lorenzo-Luaces, P.; Valdés, O.; Hernandez, Y.</b> (2009). Repair of UVB-damaged skin by the antioxidant sulphated flavone glycoside thalassiolin B isolated from the marine plant <i>Thalassia testudinum</i> Banks ex König. <i>Mar. Biotechnol. 11(1)</i>: 74-80. <a href=\"https://dx.doi.org/10.1007/s10126-008-9123-8\" target=\"_blank\">https://dx.doi.org/10.1007/s10126-008-9123-8</a>","BEntID":125690,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Mar. Biotechnol. 11(1)</i>: 74-80. <a href=\"https://dx.doi.org/10.1007/s10126-008-9123-8\" target=\"_blank\">https://dx.doi.org/10.1007/s10126-008-9123-8</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Regalado, E.L.; Rodríguez, M.; Menéndez, R.; Concepción, Á.A.; Nogueiras, C.; Laguna, A.; Rodríguez, A.A.; Williams, D.E.; Lorenzo-Luaces, P.; Valdés, O.; Hernandez, Y.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Regalado, E.L. <i>et al.</i>","Englishabstract":"Daily topical application of the aqueous ethanolic extract of the marine sea grass, <i>Thalassia testudinum</i>, on mice skin exposed to UVB radiation resulted in a dose-dependent recovery of the skin macroscopic alterations over a 6-day period. Maximal effect (90%) occurred at a dose of 240 µg/cm<sup>2</sup>, with no additional effects at higher doses. Bioassay-guided fractionation of the plant extract resulted in the isolation of thalassiolin B (1). Topical application of 1 (240 µg/cm<sup>2</sup>) markedly reduces skin UVB-induced damage. In addition, thalassiolin B scavenged 2,2-diphenyl-2-picrylhydrazyl radical with an EC<sub>50</sub>=100 ?g/ml. These results suggest that thalassiolin B is responsible for the skin-regenerating effects of the crude extract of <i>T. testudinum</i>. 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