{"refrec":{"BRefID":134074,"RR":"<b>Fagutao, F.F.; Yasuike, M.; Caipang, C.M.; Kondo, H.; Hirono, I.; Takahashi, Y.; Aoki, T.</b> (2008). Gene expression profile of hemocytes of kuruma shrimp, <i>Marsupenaeus japonicus</i> following peptidoglycan stimulation. <i>Mar. Biotechnol. 10(6)</i>: 731-740. <a href=\"https://dx.doi.org/10.1007/s10126-008-9110-0\" target=\"_blank\">https://dx.doi.org/10.1007/s10126-008-9110-0</a>","BEntID":128003,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Mar. Biotechnol. 10(6)</i>: 731-740. <a href=\"https://dx.doi.org/10.1007/s10126-008-9110-0\" target=\"_blank\">https://dx.doi.org/10.1007/s10126-008-9110-0</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Fagutao, F.F.; Yasuike, M.; Caipang, C.M.; Kondo, H.; Hirono, I.; Takahashi, Y.; Aoki, T.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Fagutao, F.F. <i>et al.</i>","Englishabstract":"Shrimps are believed to lack an adaptive immune system and therefore rely heavily on their innate immune mechanisms to ward off pathogens. Moreover, their innate defense reactions are triggered by bacterial and fungal cell wall components such as lipopolysaccharides, peptidoglycan and β-glucans. In this study, we used microarray to examine the gene expression profile of kuruma shrimp, <i>Marsupenaeus japonicus</i>, after stimulation with peptidoglycan. Subsequent results show that the number of upregulated genes and percentage of differential expression (21%) was highest at day 1 poststimulation. Differentially expressed genes in day 7 and day 14, on the other hand, were 3.25% and 11.21%, respectively. Sixty-one (61) genes of unknown function were found to have responded outright to peptidoglycan (PG) stimulation. Administration of PG also caused increases in the expressions of crustin, lysozyme, and a few antibacterial peptides, all of which are known to be involved in crustacean immune response. 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