Document of bibliographic reference 134581

BibliographicReference record

Type
Bibliographic resource
Type of document
Journal article
BibLvlCode
AM
Title
Uptake of dieldrin and dieldrin-induced changes in the activities of microsomal liver enzymes of the marine flatfish Pleuronectes platessa L.
Abstract
During a 30-day exposure of plaice (P. platessa) to 0.4 µg dieldrin l-1 seawater, an investigation was carried out to study the influence of dieldrin uptake by the liver on the in vitro activities of xenobiotic metabolizing microsomal liver enzymes. It appears that dieldrin suppresses the activity of aminopyrine demethylase, at a steady state level of dieldrin in the liver (5 mg.kg-1, wet weight), which is reached after 2 weeks' exposure. Aniline hydroxylase is not much influenced, although there is some indication that dieldrin temporarily promotes the activity of this enzyme system. However, this was found only once and must be verified in further studies. This enhancement of the activity of aniline hydroxylase coincides with a decrease of the accumulation rate of dieldrin in the liver, which leads to the steady state level. However, the conc of dieldrin in muscle tissue continues to increase during the entire expt, even at a higher accumulation rate, after the steady state level of dieldrin has been reached in the liver.
Bibliographic citation
Vink, G.J. (1975). Uptake of dieldrin and dieldrin-induced changes in the activities of microsomal liver enzymes of the marine flatfish Pleuronectes platessa L., in: Koeman, J.H. et al. (Ed.) Sublethal effects of toxic chemicals on aquatic animals. pp. 145-157
Topic
Marine

Authors

author

thesaurus terms

term
Enzymes (term code: 2820 - defined in term set: ASFA Thesaurus List)
Insecticides (term code: 4338 - defined in term set: ASFA Thesaurus List)
Liver (term code: 4794 - defined in term set: ASFA Thesaurus List)
Marine pollution (term code: 5015 - defined in term set: ASFA Thesaurus List)
Musculoskeletal system (term code: 96783 - defined in term set: Transportation Research Thesaurus)
Pollution effects (term code: 6392 - defined in term set: ASFA Thesaurus List)

taxonomic terms

taxonomic terms associated with this publication
Pleuronectes platessa (Linnaeus, 1758) [Plaice]

Document metadata

date created
2009-04-29
date modified
2009-04-29