Document of bibliographic reference 134853

BibliographicReference record

Type
Bibliographic resource
Type of document
Journal article
BibLvlCode
AS
Title
Mixed function oxygenases and xenobiotic detoxication/toxication systems in bivalve molluscs
Abstract
Components of a xenobiotic detoxication/toxication system involving mixed function oxygenases are present in Mytilus edulis. Our paper critically reviews the recent literature on this topic which reported the apparent absence of such a system in bivalve molluscs and attempts to reconcile this viewpoint with our own findings on NADPH neotetrazolium reductase, glucose-6-phosphate dehydrogenase, aldrin epoxidation and other reports of the presence of mixed function oxygenases. New experimental data are presented which indicate that some elements of the detoxication/toxication system in M. edulis can be induced by aromatic hydrocarbons derived from crude oil. This includes a brief review of the results of long-term experiments in which mussels were exposed to low concentrations of the water accommodated fraction of North Sea crude oil (7.7-68 µg 1-1) in which general stress responses such as reduced physiological scope for growth, cytotoxic damage to lysosomal integrity and cellular damage are considered as characteristics of the general stress syndrome induced by the toxic action of the xenobiotics. In addition, induction in the blood cells of microsomal NADPH neotetrazolium reductase (associated with mixed function oxygenases) and the NADPH generating enzyme glucose-6-phosphate dehydrogenase are considered to be specific biological responses to the presence of aromatic hydrocarbons. The consequences of this detoxication/toxication system forMytilus edulis are discussed in terms of the formation of toxic electrophilic intermediate metabolites which are highly reactive and can combine with DNA, RNA and proteins with subsequent damage to these cellular constituents. Implications for neoplasms associated with the blood cells are also discussed. Finally, in view of the increased use of mussel species in pollutant monitoring programmes, the induction phenomenon which is associated with microsomal enzymes in the blood cells is considered as a possible tool for the detection of the biological effects of environmental contamination by low concentrations of certain groups of organic xenobiotics.
WebOfScience code
https://www.webofscience.com/wos/woscc/full-record/WOS:A1980KS70700024
Bibliographic citation
Moore, M.N.; Livingstone, D.R.; Donkin, P.; Bayne, B.L.; Widdows, J.; Lowe, D.M. (1980). Mixed function oxygenases and xenobiotic detoxication/toxication systems in bivalve molluscs. Helgol. Meeresunters. 33(1-4): 278-291. https://dx.doi.org/10.1007/BF02414753
Topic
Marine
Is peer reviewed
true
Access rights
open access
Is accessible for free
true

Authors

author
Name
Michael Moore
author
Name
David Livingstone
author
Name
Peter Donkin
author
Name
Brian Bayne
author
Name
John Widdows
author
Name
David M. Lowe

Links

referenced creativework
type
DOI
accessURL
https://dx.doi.org/10.1007/BF02414753

thesaurus terms

term
Enzymes (term code: 2820 - defined in term set: ASFA Thesaurus List)
Metabolism (term code: 5142 - defined in term set: ASFA Thesaurus List)
Oil pollution (term code: 5752 - defined in term set: ASFA Thesaurus List)
Organic compounds (term code: 88447 - defined in term set: CSA Technology Research Database Master Thesaurus)

taxonomic terms

taxonomic terms associated with this publication
Mytilus edulis

Document metadata

date created
2009-05-05
date modified
2021-02-24