{"refrec":{"BRefID":135906,"RR":"<b>Solem, M.L.; Jiang, Z.D.; Gerwick, W.H.</b> (1989). Three new and bioactive icosanoids from the temperate red marine alga <i>Farlowia mollis</i>. <i>Lipids 24(4)</i>: 256-260","BEntID":129771,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Lipids 24(4)</i>: 256-260","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Solem, M.L.; Jiang, Z.D.; Gerwick, W.H.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Solem, M.L.; Jiang, Z.D.; Gerwick, W.H.","Englishabstract":"Three new dihydroxyicosanoids, 12(R),13(R)-dihydroxyicosa-5(Z), 8(Z),10(E),14(Z)-tetraenoic acid, 12(R),13(R)-dihydroxyicosa-5(Z), 8(Z),10(E),10(Z),17(Z)-pentaenoic acid and 10(R*),11(R*)-dihydroxyoctadeca-6(Z),8(E),12(Z)-trienoic acid, have been isolated from a previously unstudied temperate red marine alga, <i>Farlowia mollis</i> (Cryptonemiales, Rhodophyta). The structures of these new metabolites have been deduced from detailed nuclear magnetic resonance and mass spectrometry analyses on stabilized diacetate-methyl esters and stereochemistry deduced by1H NMR couplings and CD analysis of a dibenzoate derivative. Collectively, these new natural products modulate fMLP-induced superoxide anion generation in human neutrophils, inhibit the conversion of arachidonic acid to lipoxygenase products by human neutrophils, and inhibit the functioning of the dog kidney Na+/K+ ATPase.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Three new and bioactive icosanoids from the temperate red marine alga <i>Farlowia mollis</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":1989,"MonPub":null,"DateUpdate":"2009-05-20","DateCreate":"2009-05-20","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":1},"refs":null,"anarec":{"AnaID":135906,"PubliDate":1989,"Pagination":"256-260","XtraPublOfAnaID":null,"ISBN":null,"Volume":"24","Issue":"4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43512,"SerRR":"Lipids. Springer: Heidelberg.  ISSN 0024-4201; e-ISSN 1558-9307","StandardTitleSer":"Lipids","ISSN":"0024-4201","AbbrevSer":"Lipids","StandardTitleMon":null,"StartPage":256,"Pages":5,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Solem","Firstname":"Michele","Initials":"M.L.","Affiliation":null,"Discriminator":null,"CorporateFlag":1,"BEntID":129771,"AutID":87150,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Jiang","Firstname":"Zhi","Initials":"Z.D.","Affiliation":null,"Discriminator":null,"CorporateFlag":1,"BEntID":129771,"AutID":87151,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Gerwick","Firstname":"William","Initials":"W.H.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":129771,"AutID":80765,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":149065,"LibID":36,"BRefID":135906,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"149065","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Springer","City":"Heidelberg"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":129771,"AbstractFlag":-1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":129771,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":null,"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Dewitte, Elien, E.","newSesDate":{"date":"2009-05-20 11:24:13.593000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Dewitte, Elien, E.","updSesDate":{"date":"2009-05-20 11:24:13.593000","timezone_type":3,"timezone":"Europe/Brussels"}}}