{"refrec":{"BRefID":17363,"RR":"<b>Agata, K.</b> (2001). The regeneration system of planarians. <i>Belg. J. Zool. 131(Suppl. 1)</i>: 101","BEntID":17363,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Belg. J. Zool. 131(Suppl. 1)</i>: 101","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":1,"BrackishFlag":0,"TerrestrialFlag":1,"Authorstring":"Agata, K.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Agata, K.","Englishabstract":"Neoblasts, which are classically defined as prospective totipotent stem cells containing germ plasm-like granules, supporting planarian regeneration, now have been identified by expression of the DjvlgA and DjPTK3 genes, coding for a vasa-type ATP-dependent RNA helicase and a receptor-type tyrosin kinase, respectively. DjvlgA- and DjPTK3-positive cells are distributed in the mesenchymal space from head to tail, participating in formation of blastema and organ rudiments during regeneration. In X-ray-irradiated planarians, which had lost regenerative capacity, the number of DjvlgA-expressing cells decreased drastically. When fragments containing neoblasts are transplanted into X-ray irradiated hosts, they can restore regenerative ability. We have shown propagation and migration of stem cells by chimeric analysis. Interestingly, we found that neoblasts begin to transcribe tissue-specific genes in a position-dependent manner, while they are still in the mesenchymal space. This occurs prior to their migration to the organ rudiments or blastema, and at a time when they are not yet morphologically distinguishable as neoblasts. We speculate that the mRNAs transcribed in the stem cells may be trapped in a complex with RNA helicase(s), forming a \"chromatoid body\", and are not translated into protein until they migrate to the rudiment. After formation of the rudiments, these committed cells may receive a signal for organogenesis and then start to translate these mRNAs as well as to express pattern formation genes for organogenesis.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"The regeneration system of planarians","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2001,"MonPub":null,"DateUpdate":"2021-02-16","DateCreate":"2001-09-05","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":1},"refs":null,"anarec":{"AnaID":17363,"PubliDate":2001,"Pagination":"101","XtraPublOfAnaID":null,"ISBN":null,"Volume":"131","Issue":"Suppl. 1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":44108,"SerRR":"Belgian Journal of Zoology. Koninklijke Belgische Vereniging voor Dierkunde = Société royale zoologique de Belgique: Gent.  ISSN 0777-6276; e-ISSN 2295-0451","StandardTitleSer":"Belgian Journal of Zoology","ISSN":"0777-6276","AbbrevSer":"Belg. J. Zool.","StandardTitleMon":null,"StartPage":101,"Pages":101,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":[{"YBRefID":17244,"RefStrFull":"<b>Saló, E.; Watson, N.; Schockaert, E. (Ed.)</b> (2001). Proceedings of the 9<sup>th</sup> International Symposium on the Biology of the Turbellaria, Barcelona, Spain, June 2000. <i>Belgian Journal of Zoology</i>, 131(Suppl. 1). Koninklijke Belgische Vereniging voor Dierkunde = Société royale zoologique de Belgique: Diepenbeek. 236 pp.","RelID":10,"Relation":"Also appears in","StandardTitle":"Proceedings of the 9<sup>th</sup> International Symposium on the Biology of the Turbellaria, Barcelona, Spain, June 2000"}],"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Agata","Firstname":"Kiyokazu","Initials":"K.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":17363,"AutID":21270,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":358132,"LibID":36,"BRefID":17363,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"358132","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":[{"LitStyID":16,"Style":"Summary"}],"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Koninklijke Belgische Vereniging voor Dierkunde = Société royale zoologique de Belgique","City":"Gent"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":17363,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":17363,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":null,"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"VLIZ2000\\Myriam","newSesDate":{"date":"2001-09-05 13:03:46.373000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2021-02-16 06:24:26.647000","timezone_type":3,"timezone":"Europe/Brussels"}}}