{"refrec":{"BRefID":1906,"RR":"<b>Maestro, M.A.; Planas, J.V.; Gutiérrez, J.; Moriyama, S.; Swanson, P.</b> (1995). Effects of insulin-like growth factor I (IGF-I) on steroid production by isolated ovarian theca and granulosa layers of preovulatory coho salmon. <i>Neth. J. Zool. 45(1-2)</i>: 143-146","BEntID":1906,"PublicFlag":1,"CheckedFlag":0,"wosflag":null,"vabbflag":null,"RefStringPartII":". <i>Neth. J. Zool. 45(1-2)</i>: 143-146","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Maestro, M.A.; Planas, J.V.; Gutiérrez, J.; Moriyama, S.; Swanson, P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Maestro, M.A. <i>et al.</i>","Englishabstract":"The effects of recombinant human and salmon insulin-like growth factor-I (IGF-I) on <i>in vitro</i> steroid production by isolated theca and granulosa cell-layers of the preovulatory coho salmon ovary were examined. Prior to germinal vesicle breakdown (GVDB), IGF-I decreased basal theca cell-layer production of testosterone (T) and 17 alfa-hydroxyprogestrone (17-OHP) and also inhibited the stimulatory effects of gonadotropin II (GTH II) on T production. After GVBD, IGF-I lowered the GTH II-induced production of both steroids by theca cells. 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