{"refrec":{"BRefID":199602,"RR":"Uno, K.; Chaweepack, T.; Ruangpan, L. (2010). Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell. Aquacult. Int. 18(6): 1003-1015. https://dx.doi.org/10.1007/s10499-009-9318-7","BEntID":191895,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". Aquacult. Int. 18(6): 1003-1015. https://dx.doi.org/10.1007/s10499-009-9318-7","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Uno, K.; Chaweepack, T.; Ruangpan, L.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Uno, K.; Chaweepack, T.; Ruangpan, L.","Englishabstract":"The present study examined the pharmacokinetics and bioavailability of oxytetracycline (OTC) in vannamei shrimp (Penaeus vannamei) after intra-sinus (10 mg/kg) and oral (10 and 50 mg/kg) administration and also investigated the net changes of OTC residues in the shrimp after the thermal, acid and alkaline processing methods. The hemolymph concentrations of OTC after intra-sinus dosing were best described by a two-compartment open model. The oral bioavailability was found to be 48.2 and 43.6% at doses of 10 and 50 mg OTC/kg, respectively. The peak hemolymph concentrations after 10 and 50 mg OTC/kg doses were 3.37 and 17.4 μg/ml; the times to peak hemolymph concentrations were 7 and 10 h. The elimination half-lives were found to be 15.0 and 11.5 h for the low and high dose, respectively. The residual OTC was rapidly eliminated from muscle with the elimination half-life value of 19.4 and 15.4 h, respectively, for the groups treated with doses of 10 and 50 mg/kg. The residual OTC levels in the muscle fell below the MRL (0.2 μg/g) at 72 and 96-h post-dosing at dose levels of 10 or 50 mg/kg, respectively. Residual OTC levels in muscle and shell were approximately 20–50% lower in the thermal treatment such as boiling, baking and frying. By the acid treatment, OTC residues were reduced to >80%, while those were reduced to around 30% by alkaline treatment.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Pharmacokinetics and bioavailability of oxytetracycline in vannamei shrimp (Penaeus vannamei) and the effect of processing on the residues in muscle and shell","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-10 01:31:40.536520","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Penaeus vannamei; Oxytetracycline; Pharmacokinetics; Bioavailability;Processing","OtherDescriptors":null,"Notes":null,"AnaPub":2010,"MonPub":null,"DateUpdate":"2020-11-03","DateCreate":"2010-10-26","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000282316700003","VABBcode":null,"OpenAcc":0,"DOI":"10.1007/s10499-009-9318-7"},"refs":null,"anarec":{"AnaID":199602,"PubliDate":2010,"Pagination":"1003-1015","XtraPublOfAnaID":null,"ISBN":null,"Volume":"18","Issue":"6","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":44242,"SerRR":"Aquaculture International. Springer: London. ISSN 0967-6120; e-ISSN 1573-143X","StandardTitleSer":"Aquaculture International","ISSN":"0967-6120","AbbrevSer":"Aquacult. Int.","StandardTitleMon":null,"StartPage":1003,"Pages":13,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Uno","Firstname":"Kazuaki","Initials":"K.","Affiliation":"Aichi Konan Coll, Lab Food Safety, Dept Sci Living, Aichi 4838086, Japan.","Discriminator":null,"CorporateFlag":1,"BEntID":191895,"AutID":313226,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Chaweepack","Firstname":"Tidaporn","Initials":"T.","Affiliation":"Chanthaburi Coastal Fisheries Res & Dev Ctr, Bangkaja 22000, Muang Chanthabu, Thailand.","Discriminator":null,"CorporateFlag":1,"BEntID":191895,"AutID":313227,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Ruangpan","Firstname":"Lila","Initials":"L.","Affiliation":"Minist Agr & Cooperat, Dept Fisheries, Bangkok 10900, Thailand.","Discriminator":null,"CorporateFlag":1,"BEntID":191895,"AutID":313228,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":354660,"LibID":36,"BRefID":199602,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":null,"ShelfLocCode":"354660","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"
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