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Het gebruik van nieuwe bronnen in combinatie met moderne medische technieken stelde de auteur in staat een geheel nieuw licht te werpen op dit raadselachtige verschijnsel.Harde heelmeesters beschrijft de achtergronden van ziekte en dood onder 18de-eeuwse zeelieden en soldaten en de medische zorg van de scheepschirurgijns. De auteur besteedt voornamelijk aandacht aan de situatie bij de VOC, maar gaat ook in op 's Lands Vloot en de walvisjacht. 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