{"refrec":{"BRefID":2095,"RR":"<b>Glanzman, D.L.; Lin, C.K.</b> (1994). The cellular basis of CS-US pairing efficacy for classical conditioning of <i>Aplysia's</i> withdrawal reflex: potential distribution of a Hebbian mechanism. <i>Neth. J. Zool. 44(3-4)</i>: 234-258","BEntID":2095,"PublicFlag":1,"CheckedFlag":0,"wosflag":null,"vabbflag":null,"RefStringPartII":". <i>Neth. J. Zool. 44(3-4)</i>: 234-258","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Glanzman, D.L.; Lin, C.K.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Glanzman, D.L.; Lin, C.K.","Englishabstract":"The marine snail <i>Aplysia californica</i> exhibits a simple form of associative learning-classical conditioning of its defensive withdrawel reflex. Previous cellular analyses of this form of learning have suggested that it is due to a presynapticneuronal mechanism-activity-dependent presynaptic facilitation of the monosynaptic between the sensory and motor neurons which mediate the reflex. Classical conditioning of <i>Aplysia's</i> withdrawel reflex shares with many vertebrate conditioning preparations the property of temporal contguity: conditioning is best when the conditioned stimulus (CS) precedes the unconditioned stimulus (US) by a small temporal interval. The temporal contiguity of conditioning in <i>Aplysia</i> has been accounted for by a molecular model. Specifically, it has been proposed that <i>Aplysia</i> sensory neurons possess an adenlyl cyclase that is dually regulated by Ca<sup>2+</sup> -which is elevated in the sensory neuron by the occurrence of the CS- and the facilitatory transmitter serotin (5-HT)- whose release is stimulated by the occurrence of the US. It has been further suggested that the activation of the adenylyl cyclase exhibits a temporal requirement: tha elevation of Ca<sup>2+</sup> within the sensory neuron must precede the 5-HT stimulation for optimal activation of the cyclase. Recent data from our laboratory suggest that a postsynaptic mechanism -Hebbian potentiation of sensorimotor synapses- may mediate classical conditioning of <i>Aplysia's</i> withdrawel reflex. Here we summarize these data and suggest how Hebbian potentiation of sensorimotor synapses may play a role in the temporal contiguity of conditioning in <i>Aplysia</i>.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"The cellular basis of CS-US pairing efficacy for classical conditioning of <i>Aplysia's</i> withdrawal reflex: potential distribution of a Hebbian mechanism","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":1994,"MonPub":null,"DateUpdate":"2003-01-07","DateCreate":"2000-08-24","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":0},"refs":null,"anarec":{"AnaID":2095,"PubliDate":1994,"Pagination":"234-258","XtraPublOfAnaID":null,"ISBN":null,"Volume":"44","Issue":"3-4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43566,"SerRR":"Netherlands Journal of Zoology. 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