{"refrec":{"BRefID":210692,"RR":"<b>De Prijck, K.; De Smet, N.; Rymarczyk-Machal, M.; Van Driessche, G.; Devreese, B.; Coenye, T.; Schacht, E.; Nelis, H.J.</b> (2010). <i>Candida albicans</i> biofilm formation on peptide functionalized polydimethylsiloxane. <i>Biofouling (Print) 26(3)</i>: 269-275. <a href=\"https://dx.doi.org/10.1080/08927010903501908\" target=\"_blank\">https://dx.doi.org/10.1080/08927010903501908</a>","BEntID":202614,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Biofouling (Print) 26(3)</i>: 269-275. <a href=\"https://dx.doi.org/10.1080/08927010903501908\" target=\"_blank\">https://dx.doi.org/10.1080/08927010903501908</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"De Prijck, K.; De Smet, N.; Rymarczyk-Machal, M.; Van Driessche, G.; Devreese, B.; Coenye, T.; Schacht, E.; Nelis, H.J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"De Prijck, K. <i>et al.</i>","Englishabstract":"In order to prevent biofilm formation by <i>Candida albicans</i>, several cationic peptides were covalently bound to polydimethylsiloxane (PDMS). The salivary peptide histatin 5 and two synthetic variants (Dhvar 4 and Dhvar 5) were used to prepare peptide functionalized PDMS using 4-azido-2,3,5,6-tetrafluoro-benzoic acid (AFB) as an interlinkage molecule. In addition, polylysine-, polyarginine-, and polyhistidine-PDMS surfaces were prepared. Dhvar 4 functionalized PDMS yielded the highest reduction of the number of <i>C. albicans</i> biofilm cells in the Modified Robbins Device. Amino acid analysis demonstrated that the amount of peptide immobilized on the modified disks was in the nanomole range. Poly-d-lysine PDMS, in particular the homopeptides with low molecular weight (2500 and 9600) showed the highest activity against <i>C. albicans</i> biofilms, with reductions of 93% and 91%, respectively. 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