{"refrec":{"BRefID":211288,"RR":"<b>Tollefsen, K.E.; Meys, J.F.A.; Frydenlund, J.; Stenersen, J.</b> (2002). Environmental estrogens interact with and modulate the properties of plasma sex steroid-binding proteins in juvenile Atlantic salmon (<i>Salmo salar</i>). <i>Mar. Environ. Res. 54(3-5)</i>: 697-701. <a href=\"http://dx.doi.org/10.1016/S0141-1136(02)00173-3\" target=\"_blank\">dx.doi.org/10.1016/S0141-1136(02)00173-3</a>","BEntID":203210,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Mar. Environ. Res. 54(3-5)</i>: 697-701. <a href=\"https://dx.doi.org/10.1016/S0141-1136(02)00173-3\" target=\"_blank\">https://dx.doi.org/10.1016/S0141-1136(02)00173-3</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Tollefsen, K.E.; Meys, J.F.A.; Frydenlund, J.; Stenersen, J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Tollefsen, K.E. <i>et al.</i>","Englishabstract":"Environmental chemicals may modulate the endocrine system through interaction with plasma sex steroid-binding proteins (SBP) and SBP-regulated processes. Some of these chemicals, which are known to interact with the estrogen receptor (ER), were found to bind competitively to the Atlantic salmon (<i>Salmo salar</i>) SBP and potentially disrupt the endocrine function of these proteins. Furthermore, both weakly acting (di-n-butyl phthalate) and potent estrogen mimics (ethynylestradiol), were able to induce a substantial up-regulation of circulating levels of SBP in vivo. Interestingly, modulation of SBP-levels was found to be a more sensitive endpoint than chemically induced interference with classical ER-mediated mechanisms for weakly acting estrogen mimics like di-(n-butyl) phthalate. Interference with the endocrine function of SBPs may thus introduce a novel mechanism for endocrine disruption, and give additional answers to the question why some weakly acting xenoestrogens are causing \"estrogen-like\" reproductive disturbances in developing males.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Environmental estrogens interact with and modulate the properties of plasma sex steroid-binding proteins in juvenile Atlantic salmon (<i>Salmo salar</i>)","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"endocrine disrupters; sex steroid-binding proteins; ethynylestradiol;","OtherDescriptors":null,"Notes":null,"AnaPub":2002,"MonPub":null,"DateUpdate":"2015-11-05","DateCreate":"2011-12-22","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000178360100086","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/S0141-1136(02)00173-3"},"refs":null,"anarec":{"AnaID":211288,"PubliDate":2002,"Pagination":"697-701","XtraPublOfAnaID":null,"ISBN":null,"Volume":"54","Issue":"3-5","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43357,"SerRR":"Marine Environmental Research. 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