{"refrec":{"BRefID":2167,"RR":"<b>Peretz, B.</b> (1994). The modulatory effect of acetylcholinesterase on neuronal activity is dependent on age in <i>Aplysia</i>. <i>Neth. J. Zool. 44(3-4)</i>: 395-404","BEntID":2167,"PublicFlag":1,"CheckedFlag":0,"wosflag":null,"vabbflag":null,"RefStringPartII":". <i>Neth. J. Zool. 44(3-4)</i>: 395-404","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Peretz, B.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Peretz, B.","Englishabstract":"In the addult nervous system maintenance of function is poorly understood. A possible means to maintain neuronal function is the level of excitatory input impinging on a neuron. In <i>Aplysia</i> gill motor neuron L<sub>7</sub> mediates the gill withdrawel reflex and it exhibits reduced function with increased age, resulting from infrequent excitatory inputs (Peretz et al., 1984). This production is most pronounced with ageing from mature to old <i>Aplysia</i>, who are about a 100 days older. Paralleling L<sub>7</sub>'s reduced function is reduced hemolyph acetylcholinesterase (AChE) activity in old <i>Aplysia</i> (Srivatsan et al.,1992). By increased excitatory input on L<sub>7</sub>, using stimulation of the reflex pathway in old <i>Aplysia</i>, Zolman & Peretz (1987) found that L<sub>7</sub>'s function improved. Chronic stimulation of the refex pathway in old <i>Aplysia</i> (Peretz & Srivatsan, 1993). This parallel between the level of hemolymph AChEactivity and changes of L<sub>7</sub> function led me to investigate the physiological effects of AChE on gill motor neurons: AChE was superfused over the gill motor neurons in the abdominal ganglion, and it induced increased excitability as expressed by membrane depolarization, increased spike rate and spike width, and it produced a change in the IV curve; most pronounced was a lessening of a presumed inward retification, no appreciable increase in spike rate, and little if any, increase in spike width, yet AChE did elicit membrane depolarization. These results show that AChE modulates neuronal properties, and age-related ghanges of these properties render L<sub>7</sub> less responsive AChE.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"The modulatory effect of acetylcholinesterase on neuronal activity is dependent on age in <i>Aplysia</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":1994,"MonPub":null,"DateUpdate":"2001-11-14","DateCreate":"2000-08-24","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":0},"refs":null,"anarec":{"AnaID":2167,"PubliDate":1994,"Pagination":"395-404","XtraPublOfAnaID":null,"ISBN":null,"Volume":"44","Issue":"3-4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43566,"SerRR":"Netherlands Journal of Zoology. E.J. Brill: Leiden.  ISSN 0028-2960; e-ISSN 1568-542X","StandardTitleSer":"Netherlands Journal of Zoology","ISSN":"0028-2960","AbbrevSer":"Neth. J. Zool.","StandardTitleMon":null,"StartPage":395,"Pages":10,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Peretz","Firstname":"Bert","Initials":"B.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":2167,"AutID":3969,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":null,"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"E.J. Brill","City":"Leiden"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":2167,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":null,"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"VLIZ2000\\stefaan","newSesDate":{"date":"2000-08-24 19:15:10.000000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Haspeslagh, Jan, J.","updSesDate":{"date":"2001-11-14 11:50:31.853000","timezone_type":3,"timezone":"Europe/Brussels"}}}