{"refrec":{"BRefID":217223,"RR":"<b>Lewis, R.J.</b> (2009). Conotoxins: Molecular and therapeutic targets, <b><i>in</i></b>: Fusetani, N. <i>et al.</i> (Ed.) <i>Marine toxins as research tools. Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology,</i> 46: pp. 45-65. <a href=\"http://dx.doi.org/10.1007/978-3-540-87895-7_2\" target=\"_blank\">dx.doi.org/10.1007/978-3-540-87895-7_2</a>","BEntID":208972,"PublicFlag":1,"CheckedFlag":0,"wosflag":null,"vabbflag":null,"RefStringPartII":", <b><i>in</i></b>: Fusetani, N. <i>et al.</i> <i>Marine toxins as research tools. Progress in Molecular and Subcellular Biology. Marine Molecular Biotechnology,</i> 46: pp. 45-65. <a href=\"https://dx.doi.org/10.1007/978-3-540-87895-7_2\" target=\"_blank\">https://dx.doi.org/10.1007/978-3-540-87895-7_2</a>","DocTypID":17,"DocType":"Book chapters","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Lewis, R.J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Lewis, R.J.","Englishabstract":"Marine molluscs known as cone snails produce beautiful shells and a complex array of over 50,000 venom peptides evolved for prey capture and defence. Many of these peptides selectively modulate ion channels and transporters, making them a valuable source of new ligands for studying the role these targets play in normal and disease physiology. A number of conopeptides reduce pain in animal models, and several are now in pre-clinical and clinical development for the treatment of severe pain often associated with diseases such as cancer. 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