{"refrec":{"BRefID":2176,"RR":"<b>Price, D.A.; Greenberg, M.J.</b> (1994). Comparative aspects of FMRFamide gene organization in molluscs. <i>Neth. J. Zool. 44(3-4)</i>: 421-431","BEntID":2176,"PublicFlag":1,"CheckedFlag":0,"wosflag":null,"vabbflag":null,"RefStringPartII":". <i>Neth. J. Zool. 44(3-4)</i>: 421-431","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Price, D.A.; Greenberg, M.J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Price, D.A.; Greenberg, M.J.","Englishabstract":"In pulmonate molluscs two precursors for FMRFamide-related peptides (FaRPs) are generated from a single gene by alternative splicing. One precursor gives rise to FMRFamide and FLRFamide and a few variants: the tetra-FaRPs. A second precursor gives rise to FMRFamide and FLRFamide and a few variants: the hepta-FaRPs. The tetra-FaRPs and hepta-FaRPs have mutually exclusive cellular localization and have some differing actions on neurons and muscles. Hepta-FaRPs have been found in pulmonates examined, even the most primitive species, but only in pulmonates and not other gastropods. A decapeptide FaRP isolated from the mussel <i>Mytilus</i> -ALAGDHFFRFamide- is one of the more hepta-FaRP-like peptides isolated from a non-pulmonate, and thus is a candidate homolog of the hepta-FaRPs. But we show that this decapeptide is encoded on the same exon as FMRFamide in the mussel <i>Geukensia</i>, and thus is not a real homolog of the hepta-FaRPs. Since the one and only FaRP precursor known from the opisthobranch <i>Aplysia</i> has a splice junction at a location similar to that of the tetra-FaRP prcursor of polmunates, we speculated that an alternatively-spliced form of the FMRFamide gene exists in this species to. One candidate was the precursor of a group of peptides ending in LFRFamide, but we found that this precursor has no significant sequence in common with the FMRFamide precursor. Thus their remains a dichotomy between polmunates and all other molluscs with regard to their FMRFamide genes and FMRFamide-related peptides.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Comparative aspects of FMRFamide gene organization in molluscs","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":1994,"MonPub":null,"DateUpdate":"2000-09-05","DateCreate":"2000-08-24","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:A1994QN42100021","VABBcode":null,"OpenAcc":0},"refs":null,"anarec":{"AnaID":2176,"PubliDate":1994,"Pagination":"421-431","XtraPublOfAnaID":null,"ISBN":null,"Volume":"44","Issue":"3-4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43566,"SerRR":"Netherlands Journal of Zoology. E.J. Brill: Leiden.  ISSN 0028-2960; e-ISSN 1568-542X","StandardTitleSer":"Netherlands Journal of Zoology","ISSN":"0028-2960","AbbrevSer":"Neth. J. 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