{"refrec":{"BRefID":217973,"RR":"<b>Schnitzler, J.G.; Klaren, P.H.M.; Bouquegneau, J.-M.; Das, K.</b> (2012). Environmental factors affecting thyroid function of wild sea bass (<i>Dicentrarchus labrax</i>) from European coasts. <i>Chemosphere 87(9)</i>: 1009-1017. <a href=\"http://dx.doi.org/10.1016/j.chemosphere.2011.11.039\" target=\"_blank\">http://dx.doi.org/10.1016/j.chemosphere.2011.11.039</a>","BEntID":209717,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Chemosphere 87(9)</i>: 1009-1017. <a href=\"http://dx.doi.org/10.1016/j.chemosphere.2011.11.039\" target=\"_blank\">http://dx.doi.org/10.1016/j.chemosphere.2011.11.039</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Schnitzler, J.G.; Klaren, P.H.M.; Bouquegneau, J.-M.; Das, K.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Schnitzler, J.G. <i>et al.</i>","Englishabstract":"Thyroid functional status of wild fish in relation with the contamination of their environment deserves further investigation. We here applied a multi-level approach of thyroid function assessment in 87 wild sea bass collected near several estuaries: namely the Scheldt, the Seine, the Loire, the Charente and the Gironde. Thyroxine (T<sub>4</sub>) and triiodothyronine (T<sub>3</sub>) concentrations in muscle were analyzed by radioimmunoassay. The activity of hepatic enzymes involved in extrathyroidal pathways of thyroid hormone metabolism, <i>viz.</i> deiodination, glucuronidation and sulfatation were analyzed. Last, follicle diameter and epithelial cell heights were measured. We observed changes that are predicted to lead to an increased conversion of T<sub>4</sub>–T<sub>3</sub> and lowered thyroid hormone excretion. The changes in the metabolic pathways of thyroid hormones can be interpreted as a pathway to maintain thyroid hormone homeostasis. From all compounds tested, the higher chlorinated PCBs seemed to be the most implicated in this perturbation.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Environmental factors affecting thyroid function of wild sea bass (<i>Dicentrarchus labrax</i>) from European coasts","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Dicentrarchus labrax; Persistent organic contaminants; Thyroid hormone metabolism; Deiodination; Glucoronidation; Sulfatation","OtherDescriptors":null,"Notes":null,"AnaPub":2012,"MonPub":null,"DateUpdate":"2018-05-17","DateCreate":"2012-09-06","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000303292700004","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.chemosphere.2011.11.039"},"refs":null,"anarec":{"AnaID":217973,"PubliDate":2012,"Pagination":"1009-1017","XtraPublOfAnaID":null,"ISBN":null,"Volume":"87","Issue":"9","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42564,"SerRR":"Chemosphere. 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