{"refrec":{"BRefID":226722,"RR":"<b>Bailly, P.; Becker, P.; Flammang, P.</b> (2010). Neuropeptide-amidating activity in the radial nerve cord of <i>Asterias rubens</i>, <b><i>in</i></b>: Harris, L.G. <i>et al.</i> <i>Echinoderms: Durham - Proceedings of the 12th international echinoderm conference, Durham, New Hampshire, USA, 7-11 August, 2006.</i> pp. 347-348. <a href=\"http://dx.doi.org/10.1201/9780203869543-c53\" target=\"_blank\">http://dx.doi.org/10.1201/9780203869543-c53</a>","BEntID":218440,"PublicFlag":1,"CheckedFlag":1,"wosflag":null,"vabbflag":null,"RefStringPartII":", <b><i>in</i></b>: Harris, L.G. <i>et al.</i> <i>Echinoderms: Durham - Proceedings of the 12th international echinoderm conference, Durham, New Hampshire, USA, 7-11 August, 2006.</i> pp. 347-348. <a href=\"http://dx.doi.org/10.1201/9780203869543-c53\" target=\"_blank\">http://dx.doi.org/10.1201/9780203869543-c53</a>","DocTypID":17,"DocType":"Book chapters","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Bailly, P.; Becker, P.; Flammang, P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Bailly, P. <i>et al.</i>","Englishabstract":"Many metazoan neuropeptides are amidated at their C-terminal end and this amidation appears to be critical for the biological activity of the neuropeptide. The only enzyme known to catalyze this important posttranslational modification is peptidylglycine a-amidating monooxygenase (PAM). PAM is a bifunctional enzyme made of two subunits: the peptidylglycine a-hydroxylating monooxygenase (PHM), requiring copper for its action, and the peptidyl-a-hydroxyglycine a-amidating lyase (PAL). In this study, we investigated the presence PAM-like enzymatic activity in an echinoderm. Extracts from radial nerve cords of the sea star <i>Asterias rubens</i> were incubated in vitro with fluorescent peptide substrata in the presence or absence of Cu<sup>++</sup>. The results demonstrate a Cu<sup>++</sup>-dependent amidation activity similar to the PAM action in other metazoans.","AbstractOtherLang":null,"BibLvlCode":"AM","StandardTitle":"Neuropeptide-amidating activity in the radial nerve cord of <i>Asterias rubens</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2010,"MonPub":null,"DateUpdate":"2018-05-17","DateCreate":"2013-06-18","SecASFANote":null,"ConfID":null,"PeerRev":null,"VlizCoreFlag":1,"WoScode":"WOS:000278474900052","VABBcode":null,"OpenAcc":0,"DOI":"10.1201/9780203869543-c53"},"refs":null,"anarec":{"AnaID":226722,"PubliDate":2010,"Pagination":"347-348","XtraPublOfAnaID":null,"ISBN":"978-0-415-40819-6","Volume":null,"Issue":null,"BRefMon":217748,"BRefMonRR":"<b>Harris, L.G. <i>et al.</i></b> (2010). Echinoderms: Durham - Proceedings of the 12th international echinoderm conference, Durham, New Hampshire, USA, 7-11 August, 2006. CRC Press: [s.l.]. ISBN 978-0-415-40819-6. I–XXXVI pp. <a href=\"http://dx.doi.org/10.1201/9780203869543-f\" target=\"_blank\">http://dx.doi.org/10.1201/9780203869543-f</a>","BRefXtra":null,"BRefXtraRR":null,"SerBRefID":null,"SerRR":null,"StandardTitleSer":null,"ISSN":null,"AbbrevSer":null,"StandardTitleMon":"Echinoderms: Durham - Proceedings of the 12th international echinoderm conference, Durham, New Hampshire, USA, 7-11 August, 2006","StartPage":347,"Pages":2,"ToPubliDate":null,"BRefBibLvlCode":"M","SerNotes":null,"AutString":"Harris, L.G. <i>et al.</i>"},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Bailly","Firstname":"Philippe","Initials":"P.","Affiliation":"Laboratoire de biologie marine, Université de Mons Hainaut","Discriminator":null,"CorporateFlag":0,"BEntID":218440,"AutID":162330,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"BIOMAR","InsFSN":"Université Libre de Bruxelles; Centre Interuniversitaire de Biologie Marine (ULB - UMH); Biologie Marine - UMH","ORCID":null,"PersID":12452,"InsID":1600},{"AutName":"Becker","Firstname":"Pierre","Initials":"P.","Affiliation":"Laboratoire de biologie marine, Université de Mons Hainaut","Discriminator":null,"CorporateFlag":0,"BEntID":218440,"AutID":162331,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"BIOMAR","InsFSN":"Université Libre de Bruxelles; Centre Interuniversitaire de Biologie Marine (ULB - UMH); Biologie Marine - UMH","ORCID":null,"PersID":12453,"InsID":1600},{"AutName":"Flammang","Firstname":"Patrick","Initials":"P.","Affiliation":"Laboratoire de biologie marine, Université de Mons Hainaut","Discriminator":null,"CorporateFlag":0,"BEntID":218440,"AutID":162332,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"BIOMAR","InsFSN":"Université Libre de Bruxelles; Centre Interuniversitaire de Biologie Marine (ULB - UMH); Biologie Marine - UMH","ORCID":"0000-0001-9938-1154","PersID":8123,"InsID":1600}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":null,"litstyles":[{"LitStyID":3,"Style":"Conference paper"}],"thespers":null,"arch2discl":null,"SERpubls":null,"MONpubls":[{"PublName":"CRC Press","Place":null}],"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":{"222":{"SpName":"BMB - Belgische Mariene Bibliografie","SpColID":222,"ParSpColID":null,"TopParID":null,"ShortName":"BMB","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"BMB"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":[{"AutName":"Harris","Initials":"L.G.","CorporateFlag":0,"BEntID":209493,"AutID":21643,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"AutStrTrunc":"Harris, L.G. <i>et al.</i>"},{"AutName":"Böttger","Initials":"S.A.","CorporateFlag":0,"BEntID":209493,"AutID":150852,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"AutStrTrunc":"Harris, L.G. <i>et al.</i>"},{"AutName":"Walker","Initials":"C.W.","CorporateFlag":0,"BEntID":209493,"AutID":25372,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"AutStrTrunc":"Harris, L.G. <i>et al.</i>"},{"AutName":"Lesser","Initials":"M.P.","CorporateFlag":0,"BEntID":209493,"AutID":48014,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"AutStrTrunc":"Harris, L.G. <i>et al.</i>"}],"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":218440,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"http://dx.doi.org/10.1201/9780203869543-c53","externalID":"10.1201/9780203869543-c53","URLTypeCode":"DOI","URLID":28037,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Bouchti, Zohra, Z.","newSesDate":{"date":"2013-06-18 09:59:40.190000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Lyssens, Liesbeth, L.","updSesDate":{"date":"2018-05-17 20:34:05.667000","timezone_type":3,"timezone":"Europe/Brussels"}}}