{"refrec":{"BRefID":232305,"RR":"<b>Yim, H.-S.; Cho, Y.S.; Guang, X.; Kang, S.G.; Jeong, J.-Y.; Cha, S.-S.; Oh, H.-M.; Lee, J.-H.; Yang, E.C.; Kwon, K.K.; Kim, Y.J.; Kim, T.W.; Kim, W.; Jeon, J.H.; Kim, S.-J.; Choi, D.H.; Jho, S.; Kim, H.-M.; Ko, J.; Kim, H.; Shin, Y.-A.; Jung, H.-J.; Zheng, Y.; Wang, Z.; Chen, Y.; Chen, M.; Jiang, A.; Li, E.; Zhang, S.; Hou, H.; Kim, T.H.; Yu, L.; Liu, S.; Ahn, K.; Cooper, J.; Park, S.-G.; Hong, C.P.; Jin, W.; Kim, H.-S.; Park, C.; Lee, K.; Chun, S.; Morin, P.A.; O'Brien, S.J.; Lee, H.; Kimura, J.; Moon, D.Y.; Manica, A.; Edwards, J.; Kim, B.C.; Kim, S.; Wang, J.; Bhak, J.; Lee, H.S.; Lee, J.-H.</b> (2014). Minke whale genome and aquatic adaptation in cetaceans. <i>Nature Gen. 46(1)</i>: 88-92. <a href=\"https://dx.doi.org/10.1038/ng.2835\" target=\"_blank\">https://dx.doi.org/10.1038/ng.2835</a>","BEntID":224017,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Nature Gen. 46(1)</i>: 88-92. <a href=\"https://dx.doi.org/10.1038/ng.2835\" target=\"_blank\">https://dx.doi.org/10.1038/ng.2835</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Yim, H.-S.; Cho, Y.S.; Guang, X.; Kang, S.G.; Jeong, J.-Y.; Cha, S.-S.; Oh, H.-M.; Lee, J.-H.; Yang, E.C.; Kwon, K.K.; Kim, Y.J.; Kim, T.W.; Kim, W.; Jeon, J.H.; Kim, S.-J.; Choi, D.H.; Jho, S.; Kim, H.-M.; Ko, J.; Kim, H.; Shin, Y.-A.; Jung, H.-J.; Zheng, Y.; Wang, Z.; Chen, Y.; Chen, M.; Jiang, A.; Li, E.; Zhang, S.; Hou, H.; Kim, T.H.; Yu, L.; Liu, S.; Ahn, K.; Cooper, J.; Park, S.-G.; Hong, C.P.; Jin, W.; Kim, H.-S.; Park, C.; Lee, K.; Chun, S.; Morin, P.A.; O'Brien, S.J.; Lee, H.; Kimura, J.; Moon, D.Y.; Manica, A.; Edwards, J.; Kim, B.C.; Kim, S.; Wang, J.; Bhak, J.; Lee, H.S.; Lee, J.-H.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Yim, H.-S. <i>et al.</i>","Englishabstract":"The shift from terrestrial to aquatic life by whales was a substantial evolutionary event. Here we report the whole-genome sequencing and de novo assembly of the minke whale genome, as well as the whole-genome sequences of three minke whales, a fin whale, a bottlenose dolphin and a finless porpoise. Our comparative genomic analysis identified an expansion in the whale lineage of gene families associated with stress-responsive proteins and anaerobic metabolism, whereas gene families related to body hair and sensory receptors were contracted. Our analysis also identified whale-specific mutations in genes encoding antioxidants and enzymes controlling blood pressure and salt concentration. Overall the whale-genome sequences exhibited distinct features that are associated with the physiological and morphological changes needed for life in an aquatic environment, marked by resistance to physiological stresses caused by a lack of oxygen, increased amounts of reactive oxygen species and high salt levels","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Minke whale genome and aquatic adaptation in cetaceans","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Balaenoptera bonaerensis","OtherDescriptors":null,"Notes":null,"AnaPub":2014,"MonPub":null,"DateUpdate":"2018-02-13","DateCreate":"2013-12-17","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000329113500019","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/ng.2835"},"refs":null,"anarec":{"AnaID":232305,"PubliDate":2014,"Pagination":"88-92","XtraPublOfAnaID":null,"ISBN":null,"Volume":"46","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":232304,"SerRR":"Nature Genetics. 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