{"refrec":{"BRefID":239243,"RR":"<b>Terseleer, N.; Gypens, N.; Lancelot, C.</b> (2013). Factors controlling the production of domoic acid by <i>Pseudo-nitzschia</i> (Bacillariophyceae): a model study. <i>Harmful Algae 24</i>: 45-53. <a href=\"http://dx.doi.org/10.1016/j.hal.2013.01.004\" target=\"_blank\">dx.doi.org/10.1016/j.hal.2013.01.004</a>","BEntID":230928,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Harmful Algae 24</i>: 45-53. <a href=\"https://dx.doi.org/10.1016/j.hal.2013.01.004\" target=\"_blank\">https://dx.doi.org/10.1016/j.hal.2013.01.004</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Terseleer, N.; Gypens, N.; Lancelot, C.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Terseleer, N. <i>et al.</i>","Englishabstract":"A mechanistic model has been developed to explore the factors controlling the production of domoic acid (DA) by the pennate diatom <i>Pseudo-nitzschia</i>. The idealized model allows consideration of the uncoupling between photosynthesis and growth, while DA production has been set as a secondary metabolism sharing common precursors with growth. Under growth limitation, these precursors can accumulate, resulting in an increased DA production. The model was first evaluated based on its ability to simulate the observed DA production by either silicon (Si) or phosphorus (P) limited batch cultures of <i>Pseudo-nitzschia</i> available in the literature. Sensitivity tests were further performed to explore how the ambient nutrients and the light regime (intensity and photoperiod length) are possibly directing the <i>Pseudo-nitzschia</i> toxicity. The general pattern that emerged is that excess light, in combination with Si or P limitation, favours DA production, provided nitrogen (N) is sufficient. Model simulations with varying nutrient stocks supporting <i>Pseudo-nitzschia</i> blooms under non-limiting light suggest two potential ways for nutrients to control DA production. First, N excess in comparison to available Si and P relieves DA production from its limitation by N, an absolute requirement of the DA molecule. Second, increased nutrient stocks amplify the DA production phase of the blooms (in addition to enhancing <i>Pseudo-nitzschia</i> biomass) which leads to an even more toxigenic bloom. Simulations investigating the light regime suggest a light threshold below which an important delay in DA production could be expected in <i>Pseudo-nitzschia</i> cultures. In the natural environment, the monitoring of light conditions during <i>Pseudo-nitzschia</i> blooms might help to anticipate the magnitude of the toxic event. <i>Pseudo-nitzschia</i> toxicity is indeed linked to the excess of primary carbon that accumulates during photosynthesis under growth limitation by nutrients.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Factors controlling the production of domoic acid by <i>Pseudo-nitzschia</i> (Bacillariophyceae): a model study","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Harmful algal blooms; Pseudo-nitzschia; Domoic acid; Mechanisticmodelling","OtherDescriptors":null,"Notes":null,"AnaPub":2013,"MonPub":null,"DateUpdate":"2015-11-06","DateCreate":"2014-06-19","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000317327100005","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.hal.2013.01.004"},"refs":null,"anarec":{"AnaID":239243,"PubliDate":2013,"Pagination":"45-53","XtraPublOfAnaID":null,"ISBN":null,"Volume":"24","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":45642,"SerRR":"Harmful Algae. 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