{"refrec":{"BRefID":246870,"RR":"<b>Li, X.; Yang, Q.; Dierckens, K.; Milton, L; Defoirdt, T.</b> (2014). RpoS and indole signaling control the virulence of <i>Vibrio anguillarum</i> towards gnotobiotic sea bass (<i>Dicentrarchus labrax</i>) larvae. <i>PLoS One 9(10)</i>: -. <a href=\"http://dx.doi.org/10.1371/journal.pone.0111801\" target=\"_blank\">dx.doi.org/10.1371/journal.pone.0111801</a>","BEntID":238570,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>PLoS One 9(10)</i>. <a href=\"https://dx.doi.org/10.1371/journal.pone.0111801\" target=\"_blank\">https://dx.doi.org/10.1371/journal.pone.0111801</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Li, X.; Yang, Q.; Dierckens, K.; Milton, L; Defoirdt, T.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Li, X. <i>et al.</i>","Englishabstract":"Quorum sensing, bacterial cell-to-cell communication with small signal molecules, controls the virulence of many pathogens. In contrast to other vibrios, neither the VanI/VanR acylhomoserine lactone quorum sensing system, nor the three-channel quorum sensing system affects virulence of the economically important aquatic pathogen <i>Vibrio anguillarum.</i> Indole is another molecule that recently gained attention as a putative signal molecule. The data presented in this study indicate that indole signaling and the alternative sigma factor RpoS have a significant impact on the virulence of <i>V. anguillarum</i>. Deletion of <i>rpoS</i> resulted in increased expression of the indole biosynthesis gene <i>tnaA</i> and in increased production of indole. Both <i>rpoS</i> deletion and the addition of exogenous indole (50–100 µM) resulted in decreased biofilm formation, exopolysaccharide production (a phenotype that is required for pathogenicity) and expression of the exopolysaccharide synthesis gene <i>wbfD</i>. Further, indole inhibitors increased the virulence of the <i>rpoS</i> deletion mutant, suggesting that indole acts downstream of RpoS. Finally, in addition to the phenotypes found to be affected by indole, the <i>rpoS</i> deletion mutant also showed increased motility and decreased sensitivity to oxidative stress.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"RpoS and indole signaling control the virulence of <i>Vibrio anguillarum</i> towards gnotobiotic sea bass (<i>Dicentrarchus labrax</i>) larvae","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2014,"MonPub":null,"DateUpdate":"2015-05-28","DateCreate":"2015-05-21","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000343943700152","VABBcode":null,"OpenAcc":1,"DOI":"10.1371/journal.pone.0111801"},"refs":null,"anarec":{"AnaID":246870,"PubliDate":2014,"Pagination":null,"XtraPublOfAnaID":null,"ISBN":null,"Volume":"9","Issue":"10","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":123954,"SerRR":"PLoS One. 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