Document of bibliographic reference 246974

BibliographicReference record

Type

Bibliographic resource

Type of document

Journal article

BibLvlCode

AS

Title

Marine microorganism-invertebrate assemblages: perspectives to solve the "supply problem" in the initial steps of drug discovery

Abstract

The chemical diversity associated with marine natural products (MNP) is unanimously acknowledged as the. blue gold. in the urgent quest for new drugs. Consequently, a significant increase in the discovery of MNP published in the literature has been observed in the past decades, particularly from marine invertebrates. However, it remains unclear whether target metabolites originate from the marine invertebrates themselves or from their microbial symbionts. This issue underlines critical challenges associated with the lack of biomass required to supply the early stages of the drug discovery pipeline. The present review discusses potential solutions for such challenges, with particular emphasis on innovative approaches to culture invertebrate holobionts (microorganism-invertebrate assemblages) through in toto aquaculture, together with methods for the discovery and initial production of bioactive compounds from these microbial symbionts.

WebOfScience code

https://www.webofscience.com/wos/woscc/full-record/WOS:000339989300009

Bibliographic citation

Leal, C; Sheridan, C.; Osinga, R; Dionisio, G; Rocha, M; Silva, B; Rosa, R; Calado, R (2014). Marine microorganism-invertebrate assemblages: perspectives to solve the "supply problem" in the initial steps of drug discovery. Mar. Drugs 12(7): 3929-3952. dx.doi.org/10.3390/md12073929

Topic

Marine

Is peer reviewed

true

Access rights

open access

Is accessible for free

true