{"refrec":{"BRefID":246974,"RR":"<b>Leal, C; Sheridan, C.; Osinga, R; Dionisio, G; Rocha, M; Silva, B; Rosa, R; Calado, R</b> (2014). Marine microorganism-invertebrate assemblages: perspectives to solve the \"supply problem\" in the initial steps of drug discovery. <i>Mar. Drugs 12(7)</i>: 3929-3952. <a href=\"http://dx.doi.org/10.3390/md12073929\" target=\"_blank\">dx.doi.org/10.3390/md12073929</a>","BEntID":238674,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Mar. Drugs 12(7)</i>: 3929-3952. <a href=\"https://dx.doi.org/10.3390/md12073929\" target=\"_blank\">https://dx.doi.org/10.3390/md12073929</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Leal, C; Sheridan, C.; Osinga, R; Dionisio, G; Rocha, M; Silva, B; Rosa, R; Calado, R","OrigTitleTranslFlag":0,"Authorstringtrunc":"Leal, C <i>et al.</i>","Englishabstract":"The chemical diversity associated with marine natural products (MNP) is unanimously acknowledged as the. blue gold. in the urgent quest for new drugs. Consequently, a significant increase in the discovery of MNP published in the literature has been observed in the past decades, particularly from marine invertebrates. However, it remains unclear whether target metabolites originate from the marine invertebrates themselves or from their microbial symbionts. This issue underlines critical challenges associated with the lack of biomass required to supply the early stages of the drug discovery pipeline. The present review discusses potential solutions for such challenges, with particular emphasis on innovative approaches to culture invertebrate holobionts (microorganism-invertebrate assemblages) through <i>in toto</i> aquaculture, together with methods for the discovery and initial production of bioactive compounds from these microbial symbionts.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Marine microorganism-invertebrate assemblages: perspectives to solve the \"supply problem\" in the initial steps of drug discovery","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"marine natural products; aquaculture; microbial symbionts; marineinvertebrates; pharmaceuticals","OtherDescriptors":null,"Notes":null,"AnaPub":2014,"MonPub":null,"DateUpdate":"2017-03-13","DateCreate":"2015-05-21","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000339989300009","VABBcode":null,"OpenAcc":1,"DOI":"10.3390/md12073929"},"refs":null,"anarec":{"AnaID":246974,"PubliDate":2014,"Pagination":"3929-3952","XtraPublOfAnaID":null,"ISBN":null,"Volume":"12","Issue":"7","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":113252,"SerRR":"Marine Drugs. Molecular Diversity Preservation International (MDPI): Basel.  ISSN 1660-3397; e-ISSN 1660-3397","StandardTitleSer":"Marine Drugs","ISSN":"1660-3397","AbbrevSer":"Mar. Drugs","StandardTitleMon":null,"StartPage":3929,"Pages":24,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Leal","Firstname":"M","Initials":"C","Affiliation":"Univ Aveiro, Dept Biol, P-3810193 Aveiro, Portugal.","Discriminator":null,"CorporateFlag":0,"BEntID":238674,"AutID":195955,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Sheridan","Firstname":"Christopher","Initials":"C.","Affiliation":"Biology of Marine Organisms and Biomimetics Laboratory, Research Institute for Biosciences, University of Mons","Discriminator":null,"CorporateFlag":0,"BEntID":238674,"AutID":178435,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"BOMB","InsFSN":"Université de Mons; Faculté des Sciences; Département de Biologie; Laboratoire de Biologie des Organismes Marins et Biomimétisme","ORCID":"0000-0002-2178-1841","PersID":28114,"InsID":12895},{"AutName":"Osinga","Firstname":null,"Initials":"R","Affiliation":"Wageningen Univ, Dept Fisheries & Aquaculture, NL-6700 AH Wageningen, Netherlands.","Discriminator":null,"CorporateFlag":0,"BEntID":238674,"AutID":195959,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Dionisio","Firstname":null,"Initials":"G","Affiliation":"Univ Aveiro, Dept Biol, P-3810193 Aveiro, Portugal.","Discriminator":null,"CorporateFlag":0,"BEntID":238674,"AutID":195961,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Rocha","Firstname":"RJ","Initials":"M","Affiliation":"Univ Aveiro, Dept Biol, P-3810193 Aveiro, Portugal.","Discriminator":null,"CorporateFlag":0,"BEntID":238674,"AutID":195964,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Silva","Firstname":null,"Initials":"B","Affiliation":"Univ Aveiro, Dept Biol, P-3810193 Aveiro, Portugal.","Discriminator":null,"CorporateFlag":0,"BEntID":238674,"AutID":195966,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Rosa","Firstname":null,"Initials":"R","Affiliation":"Univ Lisbon, Fac Ciencias, Ctr Oceanog, Lab Maritimo Guia, P-2750374 Cascais, Portugal.","Discriminator":null,"CorporateFlag":0,"BEntID":238674,"AutID":195968,"OrderNr":7,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Calado","Firstname":null,"Initials":"R","Affiliation":"Univ Aveiro, Dept Biol, P-3810193 Aveiro, Portugal.","Discriminator":null,"CorporateFlag":0,"BEntID":238674,"AutID":195969,"OrderNr":8,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":271739,"LibID":36,"BRefID":246974,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"271739","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Molecular Diversity Preservation International (MDPI)","City":"Basel"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":[{"Collection":"OMA - Open Marien Archief","ShortName":"OMA"},{"Collection":"VLIZ Acknowledged Publications","ShortName":"VLIZ ackn"}],"conf":null,"proj":null,"Physdatasets":null,"spcols":{"222":{"SpName":"BMB - Belgische Mariene Bibliografie","SpColID":222,"ParSpColID":null,"TopParID":null,"ShortName":"BMB","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"BMB"},"941":{"SpName":"LifeWatch Species Information Backbone","SpColID":941,"ParSpColID":39,"TopParID":39,"ShortName":"LifeWatch Species Information Backbone","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":39,"SpColPath":"VLIZ ackn/LifeWatch Species Information Backbone"},"221":{"SpName":"OMA - Open Marien Archief","SpColID":221,"ParSpColID":null,"TopParID":null,"ShortName":"OMA","URLLocation":null,"LibID":36,"OpenRepoFlag":1,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"OMA"},"39":{"SpName":"VLIZ Acknowledged Publications","SpColID":39,"ParSpColID":null,"TopParID":null,"ShortName":"VLIZ ackn","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"VLIZ ackn"},"507":{"SpName":"World Register of Marine Species","SpColID":507,"ParSpColID":null,"TopParID":null,"ShortName":"WoRMS website","URLLocation":null,"LibID":null,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"WoRMS website"},"915":{"SpName":"World Register of Marine Species (WoRMS) acknowledged","SpColID":915,"ParSpColID":941,"TopParID":39,"ShortName":"WoRMS ackn","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":39,"SpColPath":"VLIZ ackn/LifeWatch Species Information Backbone/WoRMS ackn"},"947":{"SpName":"WoRMS ackn - direct reference","SpColID":947,"ParSpColID":915,"TopParID":39,"ShortName":"WoRMS ackn - direct","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":39,"SpColPath":"VLIZ ackn/LifeWatch Species Information Backbone/WoRMS ackn/WoRMS ackn - direct"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":238674,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":238674,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.3390/md12073929","externalID":"10.3390/md12073929","URLTypeCode":"DOI","URLID":39899,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Lyssens, Liesbeth, L.","newSesDate":{"date":"2015-05-21 21:50:01.133000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2017-03-13 12:47:55.483000","timezone_type":3,"timezone":"Europe/Brussels"}}}