{"refrec":{"BRefID":247031,"RR":"<b>Peigneur, S.; Zula, A; Zidar, N; Chan-Porter, F; Kirby, R; Madge, D; Ilas, J; Kikelj, D; Tytgat, J.</b> (2014). Action of Clathrodin and analogues on voltage-gated sodium channels. <i>Mar. Drugs 12(4)</i>: 2132-2143. <a href=\"http://dx.doi.org/10.3390/md12042132\" target=\"_blank\">dx.doi.org/10.3390/md12042132</a>","BEntID":238731,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Mar. Drugs 12(4)</i>: 2132-2143. <a href=\"https://dx.doi.org/10.3390/md12042132\" target=\"_blank\">https://dx.doi.org/10.3390/md12042132</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Peigneur, S.; Zula, A; Zidar, N; Chan-Porter, F; Kirby, R; Madge, D; Ilas, J; Kikelj, D; Tytgat, J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Peigneur, S. <i>et al.</i>","Englishabstract":"Clathrodin is a marine alkaloid and believed to be a modulator of voltage-gated sodium (Na<sub>V</sub>) channels. Since there is an urgent need for small molecule Na<sub>V</sub> channel ligands as novel therapeutics, clathrodin could represent an interesting lead compound. Therefore, clathrodin was reinvestigated for its potency and Na<sub>V</sub> channel subtype selectivity. Clathrodin and its synthetic analogues were subjected to screening on a broad range of Na<sub>V</sub> channel isoforms, both in voltage clamp and patch clamp conditions. Even though clathrodin was not found to exert any activity, some analogues were capable of modulating the Na<sub>V</sub> channels, hereby validating the pyrrole-2-aminoimidazole alkaloid structure as a core structure for future small molecule-based Na<sub>V</sub> channel modulators.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Action of Clathrodin and analogues on voltage-gated sodium channels","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:01.897972","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"clathrodin; oroidin; hymenidin; voltage-gated sodium channels; sodiumchannel modulator; sponge","OtherDescriptors":null,"Notes":null,"AnaPub":2014,"MonPub":null,"DateUpdate":"2015-06-02","DateCreate":"2015-05-21","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000335759500025","VABBcode":null,"OpenAcc":1,"DOI":"10.3390/md12042132"},"refs":null,"anarec":{"AnaID":247031,"PubliDate":2014,"Pagination":"2132-2143","XtraPublOfAnaID":null,"ISBN":null,"Volume":"12","Issue":"4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":113252,"SerRR":"Marine Drugs. 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