{"refrec":{"BRefID":247099,"RR":"<b>Syrpas, M.; Ruysbergh, E.; Blommaert, L.; Vanelslander, B.; Sabbe, K.; Vyverman, W.; De Kimpe, N.; Mangelinckx, S.</b> (2014). Haloperoxidase mediated quorum quenching by <i>Nitzschia cf pellucida</i>: study of the metabolization of N-Acyl Homoserine Lactones by a benthic diatom. <i>Mar. Drugs 12(1)</i>: 352-367. <a href=\"http://dx.doi.org/10.3390/md12010352\" target=\"_blank\">dx.doi.org/10.3390/md12010352</a>","BEntID":238799,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Mar. Drugs 12(1)</i>: 352-367. <a href=\"https://dx.doi.org/10.3390/md12010352\" target=\"_blank\">https://dx.doi.org/10.3390/md12010352</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Syrpas, M.; Ruysbergh, E.; Blommaert, L.; Vanelslander, B.; Sabbe, K.; Vyverman, W.; De Kimpe, N.; Mangelinckx, S.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Syrpas, M. <i>et al.</i>","Englishabstract":"Diatoms are known to produce a variety of halogenated compounds, which were recently shown to have a role in allelopathic interactions between competing species. The production of these compounds is linked to haloperoxidase activity. This research, has shown that this system may also be involved in diatom-bacteria interactions via the H<sub>2</sub>O<sub>2</sub> dependent inactivation of a type of quorum sensing (QS) molecule,<i> i.e.</i>, <i>N</i>-ß-ketoacylated homoserine lactones (AHLs), by a natural haloperoxidase system from the benthic diatom <i>Nitzschia</i> <i>cf</i> <i>pellucida</i>. The AHL degradation pathway towards corresponding halogenated derivatives was elucidated via HPLC-MS analysis and the synthesis of a broad series of novel halogenated AHL analogues as reference compounds. Furthermore, their biological activity as quorum sensing modulators was directly compared and evaluated against a series of naturally occurring ß-keto-AHLs. 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