{"refrec":{"BRefID":247129,"RR":"<b>Lefranc, F.; Nuzzo, G; Hamdy, A; Fakhr, I; Banuls, L.M.Y.; Van Goietsenoven, G.; Villani, G; Mathieu, V.; van Soest, R; Kiss, R.; Ciavatta, L</b> (2013). <i>In vitro</i> pharmacological and toxicological effects of Norterpene Peroxides isolated from the Red Sea sponge <i>Diacarnus erythraeanus</i> on normal and cancer cells. <i>J. Nat. Prod. 76(9)</i>: 1541-1547. <a href=\"http://dx.doi.org/10.1021/np400107t\" target=\"_blank\">http://dx.doi.org/10.1021/np400107t</a>","BEntID":238829,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>J. Nat. Prod. 76(9)</i>: 1541-1547. <a href=\"https://dx.doi.org/10.1021/np400107t\" target=\"_blank\">https://dx.doi.org/10.1021/np400107t</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Lefranc, F.; Nuzzo, G; Hamdy, A; Fakhr, I; Banuls, L.M.Y.; Van Goietsenoven, G.; Villani, G; Mathieu, V.; van Soest, R; Kiss, R.; Ciavatta, L","OrigTitleTranslFlag":0,"Authorstringtrunc":"Lefranc, F. <i>et al.</i>","Englishabstract":"Eight cyclic peroxide norterpenoids, compounds 1-8, have been isolated and characterized from the Red Sea sponge <i>Diacarnus erythraeanus</i>, including two new norsesterterpene derivatives (3, 4). Among these metabolites, (-)-muqubilin A (5) (nine cell lines analyzed) and the new compounds 3 and 4 (seven cell lines analyzed) displayed mean IC50 growth inhibitory concentrations in vitro of <10 mu M, while the remaining compounds (1, 6-8) were inactive in these cancer cell lines. Compound 5 displayed no selectivity between normal and cancer cells in terms of <i>in vitro</i> growth inhibition. Quantitative video microscopy analysis carried out on (-)-muqubilin A-treated cells validated the data obtained by means of the MTT colorimetric assay, while flow cytometry analysis revealed ROS production but no induction of apoptosis in cancer cells.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"<i>In vitro</i> pharmacological and toxicological effects of Norterpene Peroxides isolated from the Red Sea sponge <i>Diacarnus erythraeanus</i> on normal and cancer cells","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:32:52.928458","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2013,"MonPub":null,"DateUpdate":"2017-03-13","DateCreate":"2015-05-21","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000330331200004","VABBcode":null,"OpenAcc":0,"DOI":"10.1021/np400107t"},"refs":null,"anarec":{"AnaID":247129,"PubliDate":2013,"Pagination":"1541-1547","XtraPublOfAnaID":null,"ISBN":null,"Volume":"76","Issue":"9","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43089,"SerRR":"Journal of Natural Products. 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