Document of bibliographic reference 247129
BibliographicReference record
- Type
- Bibliographic resource
- Type of document
- Journal article
- BibLvlCode
- AS
- Title
- In vitro pharmacological and toxicological effects of Norterpene Peroxides isolated from the Red Sea sponge Diacarnus erythraeanus on normal and cancer cells
- Abstract
- Eight cyclic peroxide norterpenoids, compounds 1-8, have been isolated and characterized from the Red Sea sponge Diacarnus erythraeanus, including two new norsesterterpene derivatives (3, 4). Among these metabolites, (-)-muqubilin A (5) (nine cell lines analyzed) and the new compounds 3 and 4 (seven cell lines analyzed) displayed mean IC50 growth inhibitory concentrations in vitro of <10 mu M, while the remaining compounds (1, 6-8) were inactive in these cancer cell lines. Compound 5 displayed no selectivity between normal and cancer cells in terms of in vitro growth inhibition. Quantitative video microscopy analysis carried out on (-)-muqubilin A-treated cells validated the data obtained by means of the MTT colorimetric assay, while flow cytometry analysis revealed ROS production but no induction of apoptosis in cancer cells.
- WebOfScience code
- https://www.webofscience.com/wos/woscc/full-record/WOS:000330331200004
- Bibliographic citation
- Lefranc, F.; Nuzzo, G; Hamdy, A; Fakhr, I; Banuls, L.M.Y.; Van Goietsenoven, G.; Villani, G; Mathieu, V.; van Soest, R; Kiss, R.; Ciavatta, L (2013). In vitro pharmacological and toxicological effects of Norterpene Peroxides isolated from the Red Sea sponge Diacarnus erythraeanus on normal and cancer cells. J. Nat. Prod. 76(9): 1541-1547. http://dx.doi.org/10.1021/np400107t
- Topic
- Marine
- Is peer reviewed
- true
Authors
- author
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- Name
- Florence Lefranc
- author
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- author
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- Name
- N Hamdy
- author
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- author
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- Name
- Laetitia Banuls
- author
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- Name
- Gwendoline Van Goietsenoven
- author
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- author
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- Name
- Véronique Mathieu
- author
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- author
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- Name
- Robert Kiss
- author
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- Name
- M Ciavatta